Protein Modification Reagents
Medchemexpress LLC Amino-PEG4-CH2COOH | 195071-49-9 | >=98.0% | 251.28 g/mol | C10H21NO6 | 100 MG
Amino-PEG4-CH2COOH is a PEG-based bifunctional linker supplied as a purified solid for use in synthetic chemistry. It provides an amino terminus and a terminal carboxylic acid for conjugation and spacer functionality in bifunctional molecules such as PROTACs and antibody-drug conjugates.
- Bifunctional linker with amino and carboxylic acid termini.
- Four-unit polyethylene glycol (PEG4) spacer for flexible linkage.
- High purity suitable for synthesis and research use.
- Low molecular weight and defined formula for analytical consistency.
- Available in small-scale research quantities for lab-scale synthesis.
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 10 MG
DBCO-PEG4-DBCO is a PEG-based bifunctional linker bearing two dibenzocyclooctyne (DBCO) groups. It is used as a click chemistry reagent for strain-promoted alkyne-azide cycloaddition (SPAAC) and as a PEG linker in PROTAC and antibody-drug conjugate (ADC) synthesis.
- Click chemistry reagent enabling SPAAC with azide-functionalized partners.
- Provides a PEG4 spacer to improve solubility and linker flexibility.
- High solubility in DMSO; manufacturer provides in vitro and in vivo formulation protocols.
- Typical purity around 97.4% and appears as a white to yellow solid.
- Suitable for use in PROTAC and ADC synthesis workflows.
Medchemexpress LLC Amino-PEG4-GGFG-Dxd | 2879227-88-8 | 1088.14 g·mol⁻1 | C53H66FN9O15 | 5 MG
Amino-PEG4-GGFG-Dxd is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) synthesis. It couples a DXd (deruxtecan) payload to a GGFG peptide-based linker via a PEG4 spacer and provides an amino functional handle for conjugation to antibodies.
- drug-linker conjugate for ADC synthesis
- contains a DXd payload linked via a cleavable GGFG peptide linker
- includes a PEG4 spacer to improve solubility and spacing
- features an amino functional handle for conjugation chemistry
- available in small milligram quantities for research use
- molecular weight 1088.14 g·mol⁻1, formula C53H66FN9O15
Medchemexpress LLC Mal-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-52-8 | 1559.62 | C74H98N10O27 | 5 MG
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a cleavable antibody-drug conjugate (ADC) drug-linker conjugate that couples a maleimide-PEG4 linker to the cytotoxic payload DMEA-PNU-159682 for use in ADC research and synthesis. It is supplied in small milligram pack sizes for preclinical research applications.
- Cleavable maleimide-PEG4 linker enabling thiol conjugation.
- Valine-citrulline (vc) dipeptide linker with PABC self-immolative spacer.
- Includes DMEA-PNU-159682 cytotoxic payload for ADC development.
- Supplied as a small-scale mg quantity suitable for research use.
- Molecular weight 1559.62 and molecular formula C74H98N10O27.
- CAS number 2259318-52-8 for unambiguous identification.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- | 1056024-94-2 | 98.0% | 247.25 | C9H17N3O5 | 10 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202206.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- | 1056024-94-2 | 98.0% | 247.25 | C9H17N3O5 | 10 G
N3-PEG3-CH2CH2COOH is an azido-terminated PEG3 carboxylic acid linker used for click chemistry and as a PROTAC and ADC linker. It contains an azide functional group for copper-catalyzed and strain-promoted azide-alkyne conjugations, is supplied as a colorless to light yellow liquid, and is highly soluble in DMSO.
- Azide-containing PEG3 spacer for click chemistry.
- Compatible with CuAAC and SPAAC conjugation reactions.
- Purity 98.0% and liquid appearance (colorless to light yellow).
- High solubility in DMSO (100 mg/mL) and protocols for in vivo formulations.
- Store protected from light at -20°C; in solvent store at -80°C for long term.
Medchemexpress LLC Aminooxy-PEG5-azide | 1919045-02-5 | 98.3% | 50 MG
Aminooxy-PEG5-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group for chemical reactions
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC m-PEG4-MS | 130955-37-2 | ≥95.0% | 286.34 | C10H22O7S | 250 MG
m-PEG4-MS is a PEG-based linker used in the synthesis of PROTAC molecules and as a cleavable linker in antibody-drug conjugates (ADCs).
- PEG-based linker for PROTACs and ADCs.
- CAS number: 130955-37-2.
- Purity: ≥95.0%.
- Molecular formula: C10H22O7S.
- Molecular weight: 286.34 g/mol.
- Package size: 250 mg.
Medchemexpress LLC Bcn-peg3-biotin | 1263166-92-2 | 95.0% | 594.76 | C29H46N4O7S | 5 MG
BCN-PEG3-Biotin is a biotinylated, non-cleavable PEG3 linker containing a bicyclononyne (BCN) group used for copper-free click chemistry and the synthesis of antibody-drug conjugates and bioconjugation workflows.
- Non-cleavable PEG3 linker enabling spacer functionality and biotin capture.
- BCN group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide partners.
- Purity 95.0% and molecular weight 594.76.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Powder stable at -20°C for up to 3 years; in solvent store at -80°C for long-term stability.
Medchemexpress LLC Mal-PEG2-VCP-NB | 2395887-69-9 | 98.3% | 783.78 g/mol | C36H45N7O13 | 50 MG
Mal-PEG2-VCP-NB is a cleavable antibody-drug conjugate (ADC) linker featuring a maleimide reactive group, a two-unit polyethylene glycol (PEG2) spacer, and a VCP NB moiety. It is supplied as a research chemical for ADC conjugation and formulation studies.
- Cleavable ADC linker containing a maleimide reactive group.
- Two-unit PEG spacer to improve solubility and flexibility.
- VCP NB moiety for payload attachment.
- Purity 98.25% and molecular weight 783.78 g/mol.
- Soluble in DMSO (100 mg/mL); sonication may be required.
- Supplied as a 50 mg powder; store at 4°C under nitrogen; in solution store -80°C up to 6 months.
Medchemexpress LLC DSPE-PEG-folate | 95.7% | 5,000 Da (average) | 50 MG
DSPE-PEG-Folate is a pegylated lipid conjugate consisting of a DSPE lipid anchor linked to a polyethylene glycol chain terminated with folic acid (average MW 5,000 Da). It is designed to incorporate into lipid bilayers or micelles and provide folate-receptor targeting for nanoparticle and drug-delivery research. Supplied for laboratory formulation and functionalization.
- Provides folate-mediated targeting to folate receptor-expressing cells.
- Incorporates into lipid bilayers and micelles for nanoparticle functionalization.
- Average molecular weight of 5,000 Da for steric stabilization and circulation.
- High purity suitable for research applications.
- Available in small research pack sizes for formulation trials.
Kyfora Bio DSPE 250 MG
DSPE (1,2-Distearoyl-rac-glycero-3-Phosphatidylethanolamine) is a saturated zwitterionic phospholipid and a derivative of phosphatidylethanolamine. It can be used in liposomal drug and gene delivery formulations. DSPE can be conjugated with PEG or PCB to develop stealth liposomes that have extended circulation time in the bloodstream.Key application(s): LNP, stealth liposomes
Medchemexpress LLC Aminooxy-amido-PEG4-propargyl | 2253965-03-4 | 97.0% | 304.34 g/mol | C13H24N2O6 | 250 MG
Aminooxy-amido-PEG4-propargyl is a viscous, colorless to light yellow PEG-based ADC linker containing an alkyne (propargyl) functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is used as a click chemistry reagent for bioconjugation and antibody-drug conjugate synthesis and is supplied at laboratory research scales.
- Non-cleavable 4-unit PEG linker.
- Contains alkyne handle for CuAAC click reactions.
- Suitable for bioconjugation and ADC synthesis.
- High purity (~97.0%) for research use.
- Available in small-scale laboratory quantities.
Chemscene ChemScene | Mal-PEG1-NHS ester | 250MG | CS-0107986 | 0.98 | 1807518-72-4| MFCD26127783 | 310.26
ChemScene | Mal-PEG1-NHS ester | 250MG | CS-0107986 | 0.98 | 1807518-72-4| MFCD26127783 | 310.26
Chemscene ChemScene | Biotin-PEG4-hydrazide | 100MG | CS-0114565 | 0.97 | 756525-97-0| MFCD09952658 | 505.63
ChemScene | Biotin-PEG4-hydrazide | 100MG | CS-0114565 | 0.97 | 756525-97-0| MFCD09952658 | 505.63
eMolecules 1334177-86-4 | Mal-amido-PEG8-acid | Broadpharm | MFCD13184956 | 592.639 | C26H44N2O13 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 1g | 249969293
Mal-amido-PEG8-acid | Broadpharm | 1334177-86-4 | MFCD13184956 | 592.639 | C26H44N2O13 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 1g | 249969293