Immunohistochemistry Kits and Reagents
Meso Scale Discovery R-PLEX Human GCPII/PSMA ASYQP
The R-PLEX Human GCPII (PSMA) Assay Sector 5 PL Kit from Meso Scale Diagnostics is a multiplex immunoassay that measures GCPII (PSMA) levels in human serum plasma and cell culture supernatant samples This assay kit utilizes electrochemiluminescence (ECL) detection technology and provides reagents for analyzing 3 plates with 96 wells per plate The assay has a testing range of 0 064 - 400 ng/mL and exhibits high sensitivity and specificity This product requires the MSD QuickPlex SQ120 instrument and provides all necessary reagents and plates for quantitative analysis of GCPII (PSMA)
Biotium Ksp-Cadherin / CDH16 (Renal Cell Marker)(CDH16/2125), CF740 conjugate, 0.1mg/mL
This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exception
Biotium Cytokeratin 8(B22.1), CF740 conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant)
MilliporeSigma DAB DILUTION BUFFER 10X CONCEN
DAB Dilution Buffer 10x Concentrate, for use with ES005; Application(s): IB, IH; 50 mL
Meso Scale Discovery R-PLEX Mouse ICAM-1 ASYQP
The R-PLEX Mouse ICAM-1 Assay Kit from Meso Scale Discovery is a multiplex immunoassay that measures mouse Intercellular Adhesion Molecule 1 (ICAM-1) in serum plasma and cell culture supernatants The assay uses electrochemiluminescence (ECL) detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision This assay requires 50 L or less sample volume and can assay up to 80 samples in duplicates in 3 5 hours The kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer calibrator and positive control This assay allows rapid reproducible quantification of mouse ICAM-1 for research use
ABclonal Technology Phospho-TDP-43/TARDBP-S409/S410 Rabbit pAb
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Cayman Chemical S-p38 MAPK InhIbItr III 5mg
A methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 µM in vitro); potently blocks the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 µM, respectively)
Seracare Life Sciences Inc HISTOMARKORANGE HRP SUBS KIT
Metal enhanced DAB technology permits detection of extremely low concetrations of tissue antigens. This kit provides a sensitive means for detecting peroxidase labeled antibodies and conjugates. HistoMark Orange contains nickel enhanced DAB that produces an orange-red DAB polymer and also exceeds the sensitivity of DAB alone. The kit contains the nuclear counterstain, Contrast GREEN, a solution of methyl green that contrasts sharply with orange. Blocking solution is provided to prevent endogenous peroxidase activity. The precipitates from HistoMark Orange are alcohol and xylene insoluble, allowing section to be mounted in aqueous or xylene-based mounting media.
OriGene Desmin (DES) CytoSection, Positive Control For IHC, ICC, & ISH, 25 Slides
The Origene Technologies Desmin (DES) CytoSection is a crucial tool for researchers, providing validated positive controls for detecting Desmin expression in immunohistochemical, immunocytochemical, and *in situ* hybridization applications. This product includes 25 FFPE slides containing HEK293T cells with transient overexpression of human Desmin, ensuring reliable and accurate experimental results, distinguishing it from other controls with its specific targeted application.
Abcam 2 mm Sagittal Mouse Brain Slicer, 1UNIT
This 2 mm Sagittal mouse brain slicer (ab243313) allows you to easily cut a brain into smaller pieces for easier imaging with objectives that have a limited working distance.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Phospho-β-Catenin-S675 Rabbit pAb
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
ABclonal Technology HBG1 Rabbit pAb
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3.
Biocare Medical, LLC Rabbit-on-Farma HRP-Polymer, 25ml
Biocares PromARKTM series introduces Rabbit-on-Farma HRP-Polymer detection. The Rabbit-on-Farma HRP-Polymer is formulated to detect rabbit polyclonal or monoclonal antibodies and is affinity purified for minimal cross-reactivity to cow, horse, pig and sheep IgG proteins. The advantages of this polymer technology are increased sensitivity, reduction of IHC steps (no avidin/biotin block or link/enzyme conjugates), minimal cross-reactivity to endogenous IgG that allows multiple species flexibility, and in most cases, tissues do not require a protein block.
ABclonal Technology Phospho-p38 MAPK-T180
The protein encoded by this gene is a member of the MAP kinase family MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation differentiation transcription regulation and development This kinase is activated by various environmental stresses and proinflammatory cytokines The activation requires its phosphorylation by MAP kinase kinases (MKKs) or its autophosphorylation triggered by the interaction of MAP3K7IP1 TAB1 protein with this kinase The substrates of this kinase include transcription regulator ATF2 MEF2C and MAX cell cycle regulator CDC25B and tumor suppressor p53 which suggest the roles of this kinase in stress related transcription and cell cycle regulation as well as in genotoxic stress response Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported
ABclonal Technology AIF1/IBA1 Rabbit pAb
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.