Mammalian cDNA
eMolecules Ambeed / 2-Methyl-6-(phenylethynyl)pyridine hydrochloride / 25mg / 570569131 / A303368 / / 219911-35-0 / MFCD02262119 / 229.710 / C14H12ClN
Ambeed / 2-Methyl-6-(phenylethynyl)pyridine hydrochloride / 25mg / 570569131 / A303368 / / 219911-35-0 / MFCD02262119 / 229.710 / C14H12ClN
ABclonal Technology IL11RA Rabbit mAb
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene.
ABclonal Technology Ran Rabbit pAb
RAN (ras-related nuclear protein) is a small GTP-binding protein in the RAS superfamily, essential for RNA and protein translocation through the nuclear pore complex. It also regulates DNA synthesis and cell cycle progression. RANs nuclear localization requires regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Besides its role in nuclear-cytosol exchange, RAN also influences microtubule network formation and organization, particularly during mitosis. RCC1 generates a high concentration of RAN-GTP near chromatin, promoting microtubule nucleation. RAN is an androgen receptor (AR) coactivator and interacts differently with polyglutamine in AR. Expansion of polyglutamine repeats in AR is linked to Kennedys disease (spinal and bulbar muscular atrophy), where weak coactivation may lead to partial androgen insensitivity.
ABclonal Technology SMN1 Rabbit mAb
This gene is part of a 500 kb inverted duplication on chromosome 5q13, containing at least four genes and repetitive elements prone to rearrangements and deletions. The telomeric and centromeric copies are nearly identical and encode the same protein, but mutations in the telomeric copy are associated with spinal muscular atrophy, while mutations in the centromeric copy do not cause disease. The difference between the two genes is a single nucleotide in exon 7, affecting exon splicing. Gene conversion events may result in varying gene copy numbers. The protein encoded by this gene localizes to the cytoplasm and nucleus, particularly to subnuclear bodies called gems near coiled bodies. It forms complexes with proteins like SIP1 and GEMIN4 and interacts with proteins involved in snRNP biogenesis, such as hnRNP U and small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms exist.