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Translatable codon sequences collected from mammalian DNA and RNA. Open reading frames (ORFs) can be used for a variety of molecular applications including gene prediction and identification of protein-coding or functional RNA-coding regions in a DNA sequence.
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This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms.
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This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms.
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A BET BD2 inhibitor (IC50s 31.62 15.85 15.85 and 39.81 nM for BRD2 BRD3 BRD4 and BRDTBD2 respectively) selective for BD2 in BRD2 BRD3 BRD4 and BRDT over BD1 in the same BRDs (IC50s >10000 nM for all)
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Glypican-3 is a protein which is encoded by the GPC3 gene in humans The protein core of GPC3 consists of two subunits where the N-terminal subunit has a size of 40 kDa and the C-terminal subunit is 30 kDa Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers Several therapeutic anti-GPC3 antibodies have been developed
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