Mammalian ORFs
ABclonal Technology p-LATS1-T1079-LATS2-T1041
The protein encoded by this gene is a putative serine threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis The protein is phosphorylated in a cell-cycle dependent manner with late prophase phosphorylation remaining through metaphase The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity indicating a role as a negative regulator of CDC2 cyclin A In addition the C-terminal kinase domain binds to its own N-terminal region suggesting potential negative regulation through interference with complex formation via intramolecular binding Biochemical and genetic data suggest a role as a tumor suppressor This is supported by studies in knockout mice showing development of soft-tissue sarcomas ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments
HORIZON DISCOVERY BIOSCIENCES LIMITED ORFEOME COLLAB. MM BMPR2 ORF
NC2603663 ORFEOME COLLAB. MM BMPR2 ORF
UNITED STATES BIOLOGICAL CORPORATION IMMUNGLOBLIN-LIKE TRANSCRIPT 2
NC2743172 IMMUNGLOBLIN-LIKE TRANSCRIPT 2
Biolegend PerCP/Cyanine5.5 anti-human CD
PerCP/Cyanine5.5 anti-human CD340 (erbB2/HER-2) [24D2]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 25 tests