Cayman Chemical BB-22 6-hydroxyisoquinoline i
An agonist of CB1 and CB2 and antagonist of GPR55 (KB 13.3 UM in aBarrestin translocation assay) a major metabolite of magnolol binds to the CB1 and CB2 receptors (Kis 2.26 and 0.416 UM respectively) inhibits forskolin-induced cAMP accumulation (EC50 9.01 and 0.17 UM respectively) reduces melanin biosynthesis as well as decreases tyrosinase protein levels by inhibiting tyrosinase maturation and increasing the rate of its degradation