General Cell Based Assays
Eurofins Discoverx PathHunter eXpress GPR171 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0415E2ACP1L)
The PathHunter GPR171 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR171 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR171 and EA-tagged β-Arrestin-2. Activation of GPR171 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress ACVRL1/ACVR2 Dimerization Assay, 2pl Kit. (93-0963E3CP0M)
The PathHunter ACVRL1/ACVR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. GDF2/BMP9) induced dimerization of ACVRL1/ACVR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR2 target protein fused to PK alongside ACVRL1 target protein fused to EA. Upon ligand-induced dimerization of ACVRL1/ACVR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery U-PLEX Rat Leptin ASY 25 PL
The Meso Scale Discovery U-PLEX Rat Leptin Assay Kit is a multiplex immunoassay that measures leptin levels in rat serum plasma and cell culture supernatants The assay uses electrochemiluminescence detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision This kit includes a 96-well plate coated with capture antibodies detection antibodies labeled with MSD SULFO-TAG calibrators and controls The assay has a lower limit of detection of 1 3 pg/mL and an upper limit of quantification of 10 000 pg/mL for leptin
Eurofins Discoverx cAMP Hunter eXpress MCHR1 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0055E2CP2L)
The cAMP Hunter MCHR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. melanin concentrating hormone) based activation of MCHR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type MCHR1, a naturally Gi/Go coupled GPCR. Upon activation of MCHR1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress HRH2 CHO-K1 GPCR Assay, 2-Plate Kit. (95-0043E2CP2M)
The cAMP Hunter HRH2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. histamine) based activation of HRH2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type HRH2, a naturally Gs coupled GPCR. Upon activation of HRH2, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CCKBR CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0191E2CP0L)
The PathHunter CCKBR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. cholecystokinin) based activation of CCKBR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCKBR and EA-tagged β-Arrestin-2. Activation of CCKBR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc LANCE Ultra Phospho-STAT5 (Tyr694/699) Detection Kit, 10,000 Assay Points
LANCE Ultra Phospho-STAT5 (Tyr694/699) Detection Kit, 10,000 Assay Points
Indigo Biosciences INDIGO BIOSCIENCES Human PrRPR Reporter Assay Kit, 1x96-well
This PrRPR/GPR10 reporter assay offers precise profiling of receptor activators and inhibitors with exceptional reproducibility. It provides high-quality, quantitative data for lead discovery and optimization. The streamlined workflow delivers actionable results in as little as 24 hr., integrating seamlessly into existing screening pipelines.
- Enables precise profiling of receptor activators and inhibitors.
- Provides high-quality, quantitative data with exceptional reproducibility.
- Streamlined workflow for rapid screening and actionable results in 24 hr.
- Integrates seamlessly into existing screening pipelines.
- Utilizes a luciferase reporter gene to measure drug-induced PrRPR activity.
- Screens test samples to quantify functional interactions against PrRPR.
- Targets PrRPR (GPR10), a Class A Peptide-GPCR family member.
Eurofins Discoverx PathHunter eXpress GHR-JAK1 Functional Assay, 10-Plate Kit. (93-0756E3CP0L)
The PathHunter GHR-JAK1 Functional assay eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting CTKs. This kit assesses GHR activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged GHR cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GLP1R Activated GPCR Internalization Assay, 10pl Kit. (93-0724E3CP0L)
The PathHunter GLP1R Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of GLP1R via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged GLP1R. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting GLP1R-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human TSLP (IL7R/CRLF2) Dimerization Cell-Based Assay Kit (DLD1)
PathHunter Human TSLP (IL7R/CRLF2) Dimerization Cell-Based Assay Kit (DLD1)
Biotium ALDH1A1 (Aldehyde Dehydrogenase 1A1) (ALDH1A1/1381), Biotin conjugate, 0.1mg/mL
Aldehyde dehydrogenase 1 family member A1 (ALDH1A1), also known as retinal dehydrogenase 1, belongs to the aldehyde dehydrogenase enzyme family, which is involved in the metabolism of alcohol. ALDH1A1 is predominantly expressed in the epithelium of testis, brain, eye, liver, kidney, as well as neural and hematopoietic stem cells. Reportedly, high ALDH1A1 expression is found in solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), compared to meningiomas and synovial sarcomas. In combination with CD34, ALDH1A1 may be useful for the differentiation among SFT, HPC, meningioma, and synovial sarcoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than othe
Biotium ALDH1A1 (Aldehyde Dehydrogenase 1A1) (ALDH1A1/1381), CF568 conjugate, 0.1mg/mL
Aldehyde dehydrogenase 1 family member A1 (ALDH1A1), also known as retinal dehydrogenase 1, belongs to the aldehyde dehydrogenase enzyme family, which is involved in the metabolism of alcohol. ALDH1A1 is predominantly expressed in the epithelium of testis, brain, eye, liver, kidney, as well as neural and hematopoietic stem cells. Reportedly, high ALDH1A1 expression is found in solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), compared to meningiomas and synovial sarcomas. In combination with CD34, ALDH1A1 may be useful for the differentiation among SFT, HPC, meningioma, and synovial sarcoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than othe
Biotium ALDH1A1 (Aldehyde Dehydrogenase 1A1) (ALDH1A1/1381), CF568 conjugate, 0.1mg/mL
Aldehyde dehydrogenase 1 family member A1 (ALDH1A1), also known as retinal dehydrogenase 1, belongs to the aldehyde dehydrogenase enzyme family, which is involved in the metabolism of alcohol. ALDH1A1 is predominantly expressed in the epithelium of testis, brain, eye, liver, kidney, as well as neural and hematopoietic stem cells. Reportedly, high ALDH1A1 expression is found in solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), compared to meningiomas and synovial sarcomas. In combination with CD34, ALDH1A1 may be useful for the differentiation among SFT, HPC, meningioma, and synovial sarcoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than othe
Revvity Health Sciences Inc HTRF Human & Mouse Phospho-β-Catenin (Thr41/ Ser33/37) Detection Kit, 500 Assay Points
HTRF Human & Mouse Phospho-β-Catenin (Thr41/ Ser33/37) Detection Kit, 500 Assay Points