General Cell Based Assays
Eurofins Discoverx PathHunter eXpress GPR27 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0334E2ACP1L)
The PathHunter GPR27 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR27 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR27 and EA-tagged β-Arrestin-2. Activation of GPR27 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CCKAR CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0190E2CP2M)
The PathHunter CCKAR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. cholecystokinin) based activation of CCKAR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCKAR and EA-tagged β-Arrestin-2. Activation of CCKAR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cayman Chemical MPO asy Buffer1X 1ea
A - and K1-opioid receptor antagonist (Kis 0.3 and 0.2 nM respectively) selective for - and K1-opioid receptors over the -opioid receptor (Ki 12.8 nM) reversibly inhibits electricity-induced twitches of isolated guinea pig ileal longitudinal muscle strips (IC50 48 nM) indicating opioid agonist activity inhibits endomorphin 1-induced conditioned place preference in mice at 0.3 UG/animal i.c.v. prevents decreases in urine output induced by fentanyl D-propoxyphene buprenorphine profadol or bromadoline in water-loaded rats at 40 mg/kg reduces hemokinin 1-induced increases in the latency to withdrawal in the tail-flick test in mice
Meso Scale Discovery R-PLEX Human Neprilysin ASY
The R-Plex Human Neprilysin Assay from Meso Scale Discovery is a 96-well plate assay using electrochemiluminescence (ECL) for quantifying human neprilysin in biological samples It features a pre-coated plate with an ECL label-conjugated antibody specific for neprilysin Samples bind to the immobilized antibody and a ruthenylated detection antibody is added ECL is induced by a read buffer and measured with the MSD instrument with the signal proportional to neprilysin levels The assay offers high sensitivity a wide dynamic range and results in 90 minutes
Revvity Health Sciences Inc HTRF Human & Mouse Phospho-CDK2 (Tyr15) Detection Kit, 10,000 Assay Points
HTRF Human & Mouse Phospho-CDK2 (Tyr15) Detection Kit, 10,000 Assay Points
Revvity Health Sciences Inc HTRF Human & Mouse Phospho-STAT1 (Tyr701) Detection Kit, 50,000 Assay Points
HTRF Human & Mouse Phospho-STAT1 (Tyr701) Detection Kit, 50,000 Assay Points
Meso Scale Discovery R-PLEX Human AXL/UFO ASY
The R-PLEX Human AXL UFO Assay from Meso Scale Diagnostics is a multiplex immunoassay kit that allows for the simultaneous quantitative measurement of AXL in human serum plasma and cell culture supernatants It utilizes Meso Scale Diagnostics electrochemiluminescent detection technology and provides high sensitivity up to 5 logs of dynamic range and low sample volume requirements This assay kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer calibrator diluent and lyophilized calibrator It can test up to 80 samples in duplicate and has a testing time of 3 5 hours
Eurofins Discoverx PathHunter eXpress mEDG1 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0476E2MCP4L)
The PathHunter mEDG1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. S1P) based activation of mEDG1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mEDG1 and EA-tagged β-Arrestin-2. Activation of mEDG1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress TAAR5 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0718E2CP1L)
The PathHunter TAAR5 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of TAAR5 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TAAR5 and EA-tagged β-Arrestin-2. Activation of TAAR5 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.