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Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
Potent endothelial lipase inhibitor with an IC50 of 49 nM
Molecular weight: 406.43
Formula: C22H22N4O4
CAS No.: 1466427-02-0
Appearance: Solid
Color: Off-white to gray
Shipping: Room temperature in continental US; may vary elsewhere
Storage: Powder: -20°C for 3 years, 4°C for 2 years; In solvent: -80°C for 6 months, -20°C for 1 month
Solubility (in vitro): DMSO: 25 mg/mL (61.51 mM; need ultrasonic; hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
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Tie2 kinase inhibitor 1 is a potent, selective small-molecule inhibitor of the Tie2 receptor tyrosine kinase with reported in vitro Tie2 IC50 = 250 nM and cellular activity (cell IC50 ≈ 232 nM). It is supplied as a high-purity solid for preclinical research into angiogenesis and anticancer mechanisms.