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HR2-984-27/PEGRx 2 #27 (G03), 185 ml - 2% v/v 1,4-Dioxane, 0.1 M Tris pH 8.0, 15% w/v Polyethylene glycol 3,350. Please note items from this supplier are non-returnable.
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A cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras; does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM); blocks Ras-mediated transformation of NIH 3T3 cells
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PD-1/PD-L1 inhibitor 1 (CAS 1675201-83-8) is a small molecule inhibitor targeting the interaction between programmed cell death protein 1 (PD-1) and its ligand PD-L1 By disrupting PD-1/PD-L1 signaling this agent restores and enhances T-cell activation demonstrating immunomodulatory properties In vitro assays (HTRF binding assay) report IC50 values ranging from 6 to 100 nM Current preclinical evidence positions PD-1/PD-L1 inhibitor 1 as a candidate compound for studying tumor immunity and infectious diseases such as hepatitis C virus infection
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PKR Inhibitor (CAS 608512-97-6) is a small molecule that selectively inhibits double-stranded RNA-dependent protein kinase (PKR) a critical regulator of translational initiation via kinase-dependent phosphorylation events With reported IC50 values of 186 210 nM this inhibitor blocks PKR autophosphorylation thereby alleviating PKR-mediated translational repression in vitro In SH-SY5Y cells PKR Inhibitor mitigates Ab-induced caspase 3 activation and protects against endoplasmic reticulum stress-associated neuronal cell death In animal models systemic administration suppresses the apoptotic PKR/eIF2 pathway without activating the mTOR/p70S6K cascade PKR Inhibitor is utilized in studies of translational control stress responses and neuroprotection mechanisms
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