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A bioactive sphingolipid; levels increase time-dependently in a nutrient deprivation-induced necroptosis model in MEF cells; reduced levels in obese patients after chronic exercise correlate with weight and fat loss; higher levels in Parkinson’s disease patients correlate with memory deficits
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CD38 inhibitor 1 (CAS 1700637-55-3) is a potent selective small molecule inhibitor targeting CD38 enzymatic activity in human and mouse systems Reported IC50 values are approximately 7 3 nM for human CD38 and 1 9 nM for mouse CD38 CD38 is implicated in intracellular calcium signaling and NAD metabolic regulation Blocking CD38 enzymatic function enables exploration of its biological roles and potential therapeutic relevance in immunological processes inflammation autoimmune disorders and cancer metabolism through both in vitro and in vivo studies
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Cantharidin (100 mg), Adipogen Life Sciences. Chemical. CAS: 56-25-7. Formula: C10H12O4. MW: 196.2. . Cantharidin is a natural toxin produced by blister beetles. It is a selective protein phosphatase 2A (PP2A) inhibitor and weakly inhibits protein phosphatases 1 (PP1). Displays > 500-fold selectivity over PP2B. Induces G2/M phase arrest and apoptosis, suppresses autophagy and inhibits cell proliferation. It is used topically against Molluscum contagiosum virus (MCV) infections and associated warts. Has shown potent anticancer activities on many types of human cancer cells.
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