Protease Inhibitors and Phosphatase Inhibitors
Medchemexpress LLC HY-112136 10mg Medchemexpress, TAO Kinase inhibitor 1 CAS:850467-66-2 Purity:>98%
Medchemexpress, HY-112136 10mg TAO Kinase inhibitor 1 CAS:850467-66-2 TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Cdk9 InhIbItr 10mg
A Cdk9 inhibitor (IC50 = 39 nM); selective for Cdk9 over Cdk1-7 (IC50s = >1,000 nM for all); inhibits PRRSV replication in PRRSV-infected primary porcine alveolar macrophages at 6 to 200 nM
Medchemexpress LLC NSC668394 25mg | 382605-72-3 | 452.10 | C17H12Br2N2O3 | 25 MG
NSC668394 is a small-molecule inhibitor that blocks ezrin phosphorylation at Thr567. It is supplied as a high-purity solid for research use and is commonly used in cellular and biochemical studies of ezrin-mediated signaling and metastatic behavior.
- Inhibits ezrin Thr567 phosphorylation.
- High purity suitable for biochemical and cellular assays.
- Supplied as an orange to red solid for ease of handling.
- Available in small-quantity vials for laboratory research.
- For research use only; not for human or veterinary use.
Cayman Chemical FAK InhIbItr 14 100mg
A direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397 (IC50 = 1 μM); no known significant effect on the activity of a range of other kinases; promotes cell detachment and inhibits cell adhesion of cells in culture; blocks tumor growth in vivo
Cayman Chemical ACE2 InhIbItr Screeng as 96Wel
Cayman’s ACE2 Inhibitor Screening Assay Kit provides a robust and EAsy-to-use platform for testing potential inhibitors of human ACE2. The assay uses an ACE2-specific fluorogenic substrate, Mca-APK (Dnp). ACE2 cleaves this substrate generating free Mca, which can be EAsily quantified using a fluorescence plate reader at excitation and emission wavelengths of 320 and 405 nm, respectively. The potent and reversible ACE2 inhibitor MLN-4760 is included as a positive control. Human ACE2 plays an important role in regulating blood pressure. It is also known to bind SARS-CoV-2 spike. This assay can be used as a counter-screen for potential drug candidates to ensure they do not interfere with the normal physiological functions of ACE2.
Abcam Serine Protease Assay Kit (SR101-Leu-CMK), 100 Tests
These Serine Protease Assay Kits enable researchers to detect intracellular chymotrypsin-like serine protease activity in vitro without lysing the cell.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Endothelial lipase inhibitor-1 | 1466427-02-0 | 98.0% | 406.43 | 10 MG
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM. It is for research use only and not sold to patients.
- Potent endothelial lipase inhibitor with an IC50 of 49 nM
Cayman Chemical JAK2 InhIbItr V 25mg
A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM; blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F
Abcam SAHA (Vorinostat), HDAC inhibitor, 50MG
MW 264.32 Da, Purity >98%. Potent non-selective HDAC inhibitor (IC₅₀ values are 10 and 20 nM for HDAC1 and HDAC3, respectively). Induces apoptosis and shows antiproliferative effects against cancer cell lines (IC₅₀ = 3 - 8 μM). Antitumor effects in vivo. No effect on class III HDACs. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PQ 401, Cell-permeable IGF1R inhibitor, 10MG
MW 341.8 Da, Purity >99%. Cell-permeable IGF1R inhibitor (IC₅₀ = 12 μM for IGF-stimulated autophosphorylation). Shows antiproliferative effects against MCF-7 breast cancer cells. Induces renal hypertrophy in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam ZM 336372, c-Raf inhibitor, 10MG
MW 389.4 Da, Purity >98%. Potent, cell-permeable and selective c-Raf inhibitor (IC₅₀ = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Topotecan hydrochloride (SKF 104864), Topoisomerase inhibitor, 50MG
MW 457.9 Da, Purity >98%. Topoisomerase I inhibitor. Water-soluble derivative of camptothecin (ab120115). Anticancer agent.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Importazole, nuclear transport receptor importin-beta inhibitor, 25MG
MW 318.42 g/mol, Purity >99%. Selective nuclear transport receptor importin-β inhibitor (IC₅₀ = 25 μM). Blocks SINC localization at the nuclear envelope. Impairs release of importin-β cargo and induces defects in defects in spindle assembly during mitosis.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical PKR InhIbItr 10mg
Binds the ATP-binding site of PKR and blocks autophosphorylation (IC50 = 186-210 nM); protects neuroblastoma cells against cell damage triggered by ER stress; prevents phosphorylation of FADD, preventing apoptosis; reduces phosphorylation of PKR and eIF2α in the brain, enhancing long-term memory storage
Cayman Chemical ENPP3 InhIbItr 4t 25mg
An ENPP3 inhibitor (IC50 = 0.15 µM); selective for ENPP3 over ENPP1 (IC50 = 41.4 µM)