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Sigma Organic Chemistry INVIVO-GEL BMP2 BIOINK SUITABLE FOR 3D BIOPRINTING APPLICATIONS | 1EA
INVIVO-GEL BMP2 BIOINK SUITABLE FOR 3D BIOPRINTING APPLICATIONS, 1EA
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UNSPSC Code: 12352200
Storage: COOLER/REFRIGERATED
Cayman Chemical AtractylenolIde III 10mg
A cereblon modulator with an IC50 value of 60 nM in a competitive TR-FRET assay has a higher affinity for cereblon than the related modulators lenalidomide (IC50 1500 nM) and pomalidomide (IC50 1200 nM) in the same assay has a greater potency for degradation of the CRL4 complex substrates Ikaros and Aiolos (EC50s 1 and 0.5 nM) as well does not degrade GSPT1 or CK1a
Cayman Chemical BaccatIn III 10mg
A naturally occurring O-methylated phenolic acid that can be enzymatically degraded by some bacteria as a source of methane or methanol inhibits aldose reductase (IC50 213 Ug/ml) proteasome activity and cancer cell proliferation
Cayman Chemical Leu15-GastrIn I amIdehuma 10mg
A fungal metabolite cytotoxic to P388 (IC50 25 UM) as well as L1210 HT-29 and A549 cancer cells (IC50s 4 5 4 2 and 5 7 Ug/ml respectively) reduces fecal worm burden by 80-90 in H contortus-infected lambs at 2 5 mg/kg
Cayman Chemical IcarIsIde I 25mg
A muscarinic receptor antagonist (IC50s 2.9 2 and 1.7 nM for M1 M2 and M3 receptors respectively) inhibits acetylcholine-induced bronchospasm in anesthetized guinea pigs (EC50 68 g/ml) prevents increases in airway resistance in a rat model of cadmium inhalation-induced chronic pulmonary inflammation with airspace enlargement at 0.2 mg/20 ml aerosolized and reduces neutrophil counts and total cell numbers in BALF and airspace enlargement in lungs when administered in combination with formoterol
Cayman Chemical TubeImosIde I 50mg
An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC50 10 UM) by inhibiting the expression of MMP-9 profoundly increases the expression of p53 by increasing protein stability in cancer cells and inhibits signaling through STAT3
Cayman Chemical 8 12-Iso-IPF2a-VI 25ug
A selective DP1 receptor agonist inhibits [3H]-PGD2 binding to isolated human platelet membranes (Ki 0.9 nM) inhibits ADP-induced human and rat platelet aggregation (IC50s 2.5 and 250 nM respectively)
Cayman Chemical 5-IPF2a-VI 50ug
A water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 24 nM) and has excellent bioavailability and tissue distribution in animals has diverse anti-tumor actions suppresses inflammation by interfering with signaling through the NF-KB pathway ameliorates high fat diet-induced renal failure
Cayman Chemical GypenosIde XVII 10mg
A phenylethanoid glycoside scavenges DPPH radicals (EC50 6.6 UM in a cell-free assay) inhibits hydrogen peroxide-induced production of ROS in a cell-free assay at 10 Ug/ml reduces increases in plasma ALT TNF-a IL-1B IL-16 and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury at 60 mg/kg prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and DOPAC levels in a mouse model of MPTP-induced Parkinsons disease improves motor performance in the rotarod test in the same model
Cayman Chemical nospIramycIn I 10mg
A PI3K inhibitor (IC50 1 nM) selective for PI3K over PI3Ka PI3KB and PI3KY (IC50s 10000 nM for all) as well as a panel of 192 additional kinases and a panel of 70 ion channels and transporters at 1 UM inhibits primary human B cell proliferation (IC50 0.2 nM) and memory T cell cytokine production (IC50s 0.2-1.5 nM) inhibits the differentiation of naïve isolated human T cells into Th1 Th2 or Th17 T helper cells inhibits the proliferation of JeKo-1 Mino Rec-1 and JVM-2 lymphoma cells (IC50s 50s 2-8 nM) reduces intratumoral phosphorylation of Akt and tumor growth in a Pfeiffer mouse xenograft model from 0.1-10 mg/kg reduces proteinuria lymphadenopathy and the severity of skin lesions in an MRL/MpJ-Fas lpr mouse model of spontaneous SLE at 3 mg/kg reduces salivary levels of TNFSF13B and plasma levels of anti-SSA and anti-SSB autoantibodies in a NOD.ShiLtJ mouse model of Sjögrens syndrome
Cayman Chemical BacopasIde I 10mg
A flavoNd wth dverse bologcal actvtes reduces ApoB proten levels ACAT2 expresson and LDL degradaton n HepG2 cells from 10-200 UM nhbts gG-nducedBhexosamndase release from RBL-2H3 cells (C50 0 099 mg/ml) nhbts LPS-nduced NO producton and reduces levels of NOS L-6 and L-1B n BV-2 mcroglal cells nhbts passve cutaneous anaphylaxs n mce at 5 mg/kg reduces body weght loss colon shortenng and ulcer severty n a mouse model of TNBS-nduced ulceratve colts reduces cortcal and hppocampal neuronal apoptoss and ncreases tme spent n the target quadrant n the Morrs water maze n a mouse model of LPS-nduced neuronal nflammaton