Collagens
Cayman Chemical AstragalosIde IV 10mg
A potent agonst at four of the sphngosne-1-phosphate (S1P) receptors wth C50 values of 0 2-6 nM
Cayman Chemical AstragalosIde IV 1mg
The A1 A2A A2B and A3 adenosne receptors (ARs) are ubqutous G proten-coupled receptors The four AR subtypes have been mplcated n several areas of therapeutc nterest such as stroke and other schemc condtons as well as nflammaton neurodegeneratve dseases dabetes and sleep regulaton 13281 A3 AR antagonsts are of nterest as therapeutc agents n glaucoma agents and nflammaton CAY10498 s a potent and selectve A3 AR antagonst exhbtng a K of 37 nM wth 60 and 200-fold selectvty over A1 and A2A adenosne receptors respectvely 13281 CAY10498 s also a structural analog of reversne a dedfferentaton agent of embryonc progentor cells 12913 However no dedfferentaton effects or any connecton between A3 AR antagonsm and dedfferentaton have been demonstrated
Cayman Chemical GypenosIde XVII 1mg
A KCC2 inhibitor (IC50 568 nM) selectively inhibits KCC2 over NKCC1 (IC50 50 UM) but does inhibit the activity of adenosine A1 and A3 receptors as well as inhibits activity of L-type calcium channels at the benzothiazepine site and hERG potassium channels by 50 in a panel at 10 UM decreases potassium ion uptake by 70 in HEK293 cells expressing KCC2 at 1 UM
Cayman Chemical 10-DeacetylbaccatIn III 10mg
Selective inhibitor of NHE-1 prevents calcium overload-induced myocardial ischemia-reperfusion injury
Cayman Chemical Polygalaxnthon III 10mg
A modulator of RORY and LXR receptors an inverse agonist of RORY (IC50 100 nM) and an agonist of LXR binds to PPARY (IC50 209 nM) but does not activate it inhibits LPS-induced expression of TREM-1 in RAW 264 7 cells at 10 M inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1 FASN and SCD-1 in RAW 264 7 cells reduces severity score in a mouse model of collagen-induced arthritis at 20 mg/kg twice per day reduces blood glucose levels in a glucose tolerance test serum levels of total cholesterol and LDL body weight and fat mass in a mouse model of high-fat diet-induced obesity
Cayman Chemical 13ACtyl9DIhydrobaccatIn I 10mg
A mucolytic agent and an antioxidant inhibits LPS-induced IKK activity NF-KB-mediated transcription and production of IL-6 and IL-1B in RAW 264 7 cells prevents depletion of renal catalase and GPX and increases in renal MDA and NO levels in a rat model of cisplatin-induced nephrotoxicity at 7 5 mg/kg reduces spinal cord lipid peroxidation and destruction of spinal motor neurons in a rabbit model of spinal cord ischemia and reperfusion injury induced by thoracoabdominal aortic clamping reduces lung weight MDA and protein carbonyl levels and macrophage and neutrophil accumulation in a mouse model of oleic acid-induced acute lung injury at 150 mg/kg
Sigma Aldrich Fine Chemicals Biosciences Disposable UV-grade methac
Economical UV-grade methacrylate disposable cuvettes. Select either grooved non-optical walls for better grip or four-sided clear walls. All cells have a 10 mm pathlength and are supplied without stoppers.
Cayman Chemical ZIyuglycosIde I 25mg
A stimulator of sGC stimulates the formation of cGMP in CHO cells expressing recombinant rat sGC in the absence and presence of SNAP (EC50s 1005 and 39 nM respectively) an effect that can be reversed by ODQ inhibits phenylephrine-induced contractions in isolated rabbit saphenous artery rings rabbit aortic rings and canine femoral vein rings (IC50s 798 692 and 3072 nM respectively) decreases the coronary perfusion pressure in isolated perfused rat hearts decreases proteinuria and increases survival in an (mRenR2)27 transgenic rat model of hypertension at 3 or 10 mg/kg