Immunosuppressant Drug Testing Controls and Calibrators
AdipoGen Amikacin disulfate salt
Chemical. CAS 39831-55-5. Formula C22H43N5O13 . 2H2SO4. MW 781.76. Amikacin is a broad-spectrum aminoglycoside antibiotic and a semisynthetic analog of kanamycin. It irreversibly binds to 16S rRNA and the RNA-binding S12 protein of the 30S subunit and 50S subunit of prokaryotic ribosome and inhibits protein synthesis. It works in a concentration-dependent manner, and has better action in an alkaline environment. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains, due to its resistance to inactivating enzymes. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria. Amikacin can be used to treat non-tubercular mycobacterial infections and tuberculosis when first-line drugs fail to control the infection.
Cayman Chemical MycophenolIc AcId DGlucuro 5mg
A metabolite of mycophenolic acid; does not inhibit IMPDH type II in a cell-free assay; reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model at 6 mg/animal
Cayman Chemical Mycophenolc ACD mthyl Ste 25mg
An esterified form of mycophenolic acid; inhibits pioglitazone-induced transactivation of PPARγ in U2OS cells in a reporter assay at 1 and 10 µM; cytotoxic against a panel of seven cancer cell lines (IC50s = 0.26-23.73 µM); inhibits tumor growth in an Ehrlich murine spontaneous adenocarcinoma model and decreases the production of antibodies against sheep red blood cells in mice at 120 mg/kg; has been used as a precursor in the synthesis of mycophenolic acid β-D-glucuronide; a potential impurity in commercial preparations of mycophenolate mofetil
