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α-Factor Mating Pheromone, yeast TFA is a tridecapeptide secreted by S. cerevisiae α cells via Ste2p receptor. This product is intended for laboratory research and manufacture of substances.
Tridecapeptide secreted by S. cerevisiae α cells
White to off-white solid appearance
Soluble in water at ≥ 100 mg/mL
For research use only
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A PEGylated derivative of DSPE has been used in CuAAC and SPAAC has been used to attach VCAM-1 antibodies to the surface of liposomes encapsulating fingolimod to provide targeted delivery of fingolimod to inflamed vasculature in a mouse model of post-stroke neuroinflammation has been used to attach FMP to the surface of synthetic platelets used in a mouse model of liver injury-induced uncontrolled hemorrhage
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An analog of valeric acid; inhibits class I HDACs (IC50s = ~2 mM); the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia; inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in the Morris water maze test in the APP23 transgenic mouse model of Alzheimer's disease; has anticonvulsant activity in the pentylenetetrazol seizure threshold test in mice (ED50 = 0.71 mmol/kg); induces neurotoxicity at ≥1.2 mmol/kg
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A DDR1 inhibitor (IC50 9.4 nM) selective for DDR1 over DDR2 and Abl1 (IC50s 188 and >10000 nM respectively) and 461 additional kinases at 1 UM but does inhibit Cdk11 EPHA8 MUSK TrkA TrkB and TrkC at 1 UM selectively binds to DDR1 (Kd 4.7 nM) over Cdk11 EPHA8 MUSK and TrkA (Kds 370 550 530 and 100 nM respectively) but does bind to TrkB and TrkC (Kds 22 and 18 nM respectively) reduces phosphorylated DDR1 and phosphorylated p38 MAPK levels in primary human lung fibroblasts at 0.25-1 UM reduces bleomycin-induced pulmonary fibrosis in mice at 10 and 50 mg/kg twice per day
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This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH Multiple alternatively spliced transcript variants have been found for this gene
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