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An ionizable cationic lipid (pKa = 6.7); has been used in the formation of LNPs encapsulating siRNA or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-KC2-DMA selectively accumulate in the liver after i.v. or i.m. administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration; DLin-KC2-DMA-containing LNPs encapsulating F7-targeted siRNA reduce serum Factor VII levels in mice; DLin-KC2-DMA-containing LNPs encapsulating AR-targeted siRNA decrease serum PSA and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model
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DSG-PEG 2000 is a PEG-modified lipid that can be used with cationic lipids such as D-Lin-MC3-DMA (No A8791) to prepare cationic nanoparticles (LNP) capable of encapsulating and delivering siRNA mRNA DNA or small molecules into the cytoplasm
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1-Palmitoyl-sn-glycerol 3-phosphate sodium salt is a lysophosphatidic acid derivative used as a biochemical reagent for studies of glycerophospholipid metabolism and signaling. It is provided as a sodium salt solid intended for in vitro research and biochemical assays.
High purity suitable for sensitive analytical and biochemical experiments.
Supplied as a stable sodium salt for reliable handling and storage.
Useful for investigations of lipid metabolism and cell signaling pathways.
Available in research-scale quantities to support assay development.
Provided with product documentation such as datasheet and certificate of analysis.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More