Lipid Controls
Cayman Chemical Oleoyl EthnolamIde-d4 500UG
An endogenous incretin hormone increases intracellular cAMP levels using HEK293 cells expressing human GLP-1R (EC50 0.051 nM) reduces blood glucose levels in an OGTT in fasted mice at 30 mg/kg
Cayman Chemical Lyso-Monosialoganglioside GM1
A muscarinic acetylcholine receptor antagonist (Kds 0.11 and 0.17 nM for guinea pig atria and ileum respectively) reverses carbaminocholine- and acetylcholine-induced decreases in blood pressure in anesthetized cats (ED50s 0.591 and 1 g/kg respectively) decreases rumenal ulcer formation in rats and suppresses insulin-induced gastric secretion in dogs with gastric fistulas prevents FDM in a chick model of experimental myopia
Cayman Chemical 1 3DIoleoyl2Octnoyl Glyce 10mg
A prodrug of benazeprilat inhibits enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 2 nM) decreases the triglyceride and total cholesterol levels in normotensive rats (30 mg/kg) decreases aortic atherosclerosis in cholesterol-fed rabbits (3 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats (0.1-10 mg/kg per day) decreases proteinuria in cats with chronic kidney disease (0.5-1 mg/kg per day)
Cayman Chemical 1 3DIoleoyl2Stearoyl Glyce 5mg
A 5-HT1A receptor agonist (Ki 0.4 nM) selective for 5-HT1A over 5-HT1D 5-HT2 dopamine D1 and D2 and a1- and a2-adrenergic receptors (Kis 7.7 1000 1000 36 1000 and 1000 nM respectively) inhibits forskolin-stimulated cAMP synthesis in CHO cells transfected with human 5-HT1A induces hypothermia in mice (ED50 0.041 mg/kg) induces 5-HT syndrome as well as decreases accumulation of 5-HT and dopamine in rats (5 mg/kg) decreases arterial blood pressure and heart rate in a dose-dependent manner in spontaneously hypertensive rats reverses isolation-induced aggression in mice