TED-347 is a small-molecule, irreversible, covalent and allosteric inhibitor of the YAP-TEAD protein-protein interaction. It covalently modifies TEAD4 at Cys-367, blocks TEAD transcriptional activity, and shows cellular antitumor activity (EC50 5.9 μM; Ki 10.3 μM). The compound is supplied as a solid with high purity for research use only.
- Irreversible covalent inhibitor of YAP-TEAD interaction.
- Targets TEAD4 Cys-367 via covalent modification.
- Demonstrated cellular activity (EC50 5.9 μM; Ki 10.3 μM).
- High purity suitable for research applications.
- Available in multiple small pack sizes for experimental workflows.