Isotopically Labeled Compounds
Medchemexpress LLC Ethane-13C2-sulfonic acid, 2-amino- | 70155-54-3 | ≥99.0% | 1 MG
Taurine-13C2 is the 13C-labeled Taurine, a sulfur-containing amino acid and an organic osmolyte crucial for cell volume regulation. It functions as a substrate for bile salt formation and modulates intracellular free calcium concentration, also activating autophagy in adipocytes.
- Intended for research use only
- Can be used as a tracer for quantitative analysis
- Functions as an internal standard for quantitative analysis
- Suitable for NMR, GC-MS, or LC-MS applications
Medchemexpress LLC D-Glucose-13C-4 | 40762-22-9 | 98.0% | 100 MG
D-Glucose-13C-4 is a 13C labeled version of D-Glucose. D-Glucose, a monosaccharide, is a significant carbohydrate in biology. It functions as a carbohydrate sweetener, a vital component of general metabolism, and a crucial signaling molecule involved in cellular metabolic status and responses to biotic and abiotic stress. This product is intended solely for research purposes.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis through methods like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, such as carbon, are incorporated into drug molecules for quantitation during drug development.
- Deuteration can potentially influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Cytidine-13C | 201996-57-8 | 99.0% | 25 MG
Cytidine-13C is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and a component of RNA. It is also a precursor of uridine and controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism and catecholamine.
- 13C labeled Cytidine
- Pyrimidine nucleoside
- Component of RNA
- Precursor of uridine
- Controls neuronal-glial glutamate cycling
- Affects cerebral phospholipid metabolism
- Affects catecholamine
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Octopamine-d4 hydrochloride | 1219803-62-9 | 98.3% | 5 MG
Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. It has been shown to increase glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
- Molecular formula: C8H9D3CINO2
- Molecular weight: 192.66
- Target: Adrenergic receptor; endogenous metabolite
- Pathway: GPCR/G protein; neuronal signaling; metabolic enzyme/protease
- Storage: 4°C, sealed storage, away from moisture. In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture).
- Solubility (in vitro): DMSO: ≥ 100 mg/mL (519.05 mM); H2O: ≥ 50 mg/mL (259.52 mM)
Medchemexpress LLC Pirfenidone-d5 | 1020719-62-3 | 98.9% | 5 MG
Pirfenidone-d5 (AMR69-d5) is a deuterium labeled Pirfenidone. It acts as an antifibrotic agent by attenuating CCL2 and CCL12 production in fibrocyte cells. This compound also exhibits a growth-inhibitory effect, reducing TGF-β2 protein levels in human glioma cell lines, and possesses anti-inflammatory activities. It is intended for research use only and can serve as a tracer or an internal standard for quantitative analysis.
- Used as a tracer for quantitative analysis
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Attenuates CCL2 and CCL12 production in fibrocyte cells
- Exhibits a growth-inhibitory effect
- Reduces TGF-β2 protein levels in human glioma cell lines
- Possesses anti-inflammatory activities
Medchemexpress LLC Nateglinide-d5 | 1227666-13-8 | 98.0% | 5 MG
Nateglinide-d5 is a deuterium-labeled derivative of Nateglinide, a D-phenylalanine derivative. Nateglinide acts as an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. It inhibits ATP-sensitive K+ channels in pancreatic β-cells and is used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS
Medchemexpress LLC Riboflavin-d3 (Vitamin B2-d3) | 83-88-5 | 99.9% | 5 MG
Riboflavin-d3, also known as Vitamin B2-d3 or E101-d3, is the deuterium labeled form of Riboflavin. Riboflavin is an easily absorbed micronutrient that plays a key role in maintaining health in humans and other animals. This product is intended for research use only.
- Tracer.
- Internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS.
- Incorporation of stable heavy isotopes like deuterium into drug molecules for quantitation during drug development.
- Potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Thiamphenicol-d3-1 | 1217723-41-5 | 99.0% | 1 MG
Thiamphenicol-d3-1 is a deuterium-labeled form of Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol. It acts as a broad-spectrum antimicrobial antibiotic by binding to the 50S ribosomal subunit, inhibiting protein synthesis and resulting in a bacteriostatic effect against Gram-negative, Gram-positive aerobic, and anaerobic bacteria. Deuteration can influence the pharmacokinetic and metabolic profiles of drugs, and stable heavy isotopes are incorporated for quantitation during drug development.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Exhibits broad-spectrum antimicrobial activity
- Inhibits protein synthesis by binding to the 50S ribosomal subunit
- Effective against Gram-negative, Gram-positive aerobic, and anaerobic bacteria
Medchemexpress LLC Thioridazine-d3 hydrochloride | 1189928-36-6 | 98.3% | 1 MG
Thioridazine-d3 hydrochloride is the deuterium-labeled version of Thioridazine, which is an antagonist of dopamine receptor D2 family proteins. It demonstrates potent anti-psychotic and anti-anxiety effects. Additionally, Thioridazine is a strong inhibitor of PI3K-Akt-mTOR signaling pathways, exhibiting anti-angiogenic properties and showing antiproliferative and apoptosis induction in various cancer cell types, particularly targeting cancer stem cells (CSCs).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Sulfathiazole-d4 | 1020719-89-4 | 99.9% | 5 MG
Sulfathiazole-d4 is a deuterium labeled Sulfathiazole. Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRNA expression of CYP17, CYP19, and 3β-HSD. It increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Enhances the activity of CYP19 in human adrenal cancer cells (H295R)
- Upregulates the mRNA expression of CYP17, CYP19, and 3β-HSD
- Increases the production of 17-estradiol (E2)
- Has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish
Medchemexpress LLC Diethyltoluamide-d7 | 1219799-37-7 | 98.5% | 5 MG
Diethyltoluamide-d7 is the deuterium-labeled form of Diethyltoluamide, which is widely recognized as the primary active ingredient in insect repellents. It is formulated to offer protection against a broad spectrum of biting insects, including mosquitoes, ticks, fleas, chiggers, and leeches. This compound is intended for research purposes only.
- Deuterium labeled diethyltoluamide.
- Can be used as a tracer.
- Can serve as an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, such as deuterium, are incorporated into drug molecules for quantitation during drug development.
- Deuteration can potentially influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Thiamethoxam-d3 | 1294048-82-0 | 99.0% | 5 MG
Thiamethoxam-d3 is the deuterium labeled version of Thiamethoxam, a broad-spectrum neonicotinoid insecticide intended for research use only. Stable heavy isotopes, including deuterium, have been incorporated into drug molecules primarily for quantitation during the drug development process, as deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Can be utilized as a tracer
- Suitable as an internal standard for quantitative analysis using methods such as NMR, GC-MS, or LC-MS
Medchemexpress LLC Glyphosate-d2-1 | 99.9% | 5 MG
Glyphosate-d2-1 is a deuterium-labeled version of Glyphosate, an herbicidal derivative of the amino acid glycine. It targets and blocks the shikimate pathway in plants, a metabolic pathway not found in animals, which is essential for the synthesis of aromatic amino acids. This compound is primarily used as a tracer and internal standard in quantitative analysis.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Fingolimod-d4 | 1346747-38-3 | MFCD19704989 | 99.1% | 311.50 | 100 MG
Fingolimod-d4 is the deuterium labeled Fingolimod. It is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist and also functions as a pak1 activator and an immunosuppressant. Deuterium labeling allows its use as a tracer for quantitation during drug development and has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled
- Brain-penetrant sphingosine 1-phosphate (S1P) antagonist
- Pak1 activator
- Immunosuppressant
- Can be used as tracers for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Sphingosine-1-phosphate | 26993-30-6 | 99.5% | 379.47 | 50 MG
Sphingosine-1-phosphate (S1P) acts as an agonist for S1P1-5 receptors and serves as a ligand for GPR3, GPR6, and GPR12. It functions as an intracellular second messenger and triggers Ca2+ mobilization as an extracellular ligand for G protein-coupled receptors. S1P is a crucial lipid mediator derived from Sphingomyelin or other membrane phospholipids.
- Promotes DNA synthesis.
- Promotes cell proliferation.
- Promotes migration.
- Acts as an intracellular second messenger.
- Triggers Ca2+ mobilization.