Isotopically Labeled Compounds
Medchemexpress LLC Spironolactone-d7 | 99.96% | 100 UG
Spironolactone-d7 is the deuterium labeled version of Spironolactone, an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM and a potent antagonist of androgen receptor with an IC50 of 77 nM. It is known to promote autophagy in podocytes and is commonly used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled compound for accurate tracing
- Can be used as an internal standard in quantitative analysis
- High purity (99.96%) for reliable results
- Supports research in drug development and metabolism
- Applicable in studies related to cancer and endocrine diseases
Medchemexpress LLC Mefenamic Acid-d3 | 1189707-81-0 | 2.5 MG
Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a BBB-permeable non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM, respectively. It can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled mefenamic acid
- BBB-permeable non-steroidal anti-inflammatory agent
- Acts as a competitive inhibitor of hCOX-1 and hCOX-2
- Suitable as a tracer for research
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Ronidazole-d3 | 1015855-87-4 | MFCD09265285 | 5 MG
Ronidazole-d3 is the deuterium-labeled version of Ronidazole. It is an effective orally active antiprotozoal and anti-microbial agent used as a veterinary agent against Tritrichomonas foetus in cat models and in research for histomoniasis and swine dysentery.
- Can be used as a tracer.
- Can serve as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes can be incorporated into drug molecules as tracers for quantitation during drug development.
- Deuteration has potential to influence pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Cabozantinib-d6 | 1802168-46-2 | 98.1% | 50 MG
Cabozantinib-d6 is the deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Nadolol-d9 | 94513-92-5 | MFCD00049405 | 97.0% | 5 MG
Nadolol-d9 is a deuterium labeled Nadolol, functioning as a non-selective and orally active β-adrenergic receptors blocker. It is intended for research use only.
- Used as a tracer
- Functions as an internal standard for quantitative analysis
- Supports NMR, GC-MS, or LC-MS applications
Medchemexpress LLC Rabeprazole-d4 sodium | 117976-90-6 | 98.6% | 1 MG
Rabeprazole-d4 sodium is a deuterium-labeled version of Rabeprazole sodium, a second-generation proton pump inhibitor. It irreversibly inactivates gastric H+/K+-ATPase and induces apoptosis. This compound is suitable for research on gastric ulcerations and gastroesophageal reflux.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Penicillin V-d5 | 1356837-87-0 | 99.5% | 5 MG
Penicillin V-d5 (Phenoxymethylpenicillin-d5) is the deuterium-labeled Penicillin V. Penicillin V (Phenoxymethylpenicillin) is an orally active antibiotic that inhibits the growth of Streptococci, C. difficile, and S. aureus. It can be used for research on otitis, sinusitis, pharyngitis, and tonsillitis. The deuterium labeling allows it to be used as a tracer and an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Orally active antibiotic
- Inhibits growth of Streptococci, C. difficile, and S. aureus
- Suitable for research on otitis, sinusitis, pharyngitis, and tonsillitis
- Deuterium-labeled compound
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Diuron-d6 | 1007536-67-5 | 99.5% | 5 MG
Diuron-d6 is a deuterium-labeled version of Diuron, an orally active phenylurea herbicide. It functions by inhibiting photosynthesis in plants, specifically by blocking the formation of ATP and NADH. The compound also increases the production of Reactive Oxygen Species (ROS) and has been shown to increase p53 expression in certain cell lines. Diuron-d6 exhibits herbicidal activity against various annual and perennial broadleaf and grass weeds. Additionally, it is noted to promote DMBA/BBN-induced bladder cancer and can be utilized in breast cancer research.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Clomipramine-d3 hydrochloride | 1398065-86-5 | 100.0% | 1 MG
Clomipramine-d3 (hydrochloride) is a deuterium-labeled variant of Clomipramine hydrochloride. Clomipramine hydrochloride functions as a blocker for the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), with Ki values of 0.14, 54, and 3 nM, respectively.
- Used as a tracer.
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Acetylcholine-d4 bromide | 93449-31-1 | 98.7% | 1 MG
Acetylcholine-d4 bromide is a deuterium-labeled form of Acetylcholine bromide, intended for research use. This compound can serve as a tracer or an internal standard for various quantitative analytical methods. Deuteration, which involves incorporating stable heavy isotopes, offers potential benefits in drug development by influencing pharmacokinetic and metabolic profiles. It appears as a white to off-white solid.
- Used as a tracer for research purposes
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes into drug molecules
- May affect the pharmacokinetic and metabolic profiles of drugs
- Has a molecular weight of 230.14
- Its formula is C7H12D4BrNO2
Medchemexpress LLC Adenosine-d2 | 82741-17-1 | 99.6% | 5 MG
Adenosine-d2 is a deuterium-labeled adenosine, acting as a ubiquitous endogenous autacoid through four G protein-coupled receptors (A1, A2A, A2B, and A3). It affects almost all aspects of cellular physiology. Deuterium substitution is used in drug molecules as tracers for quantitative analysis and can influence pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Impacts cellular physiology
- Functions through G protein-coupled receptors: A1, A2A, A2B, and A3
Cayman Chemical FluvoxamIn-d4maleate 1mg
An internal standard for the quantification of fluvoxamine by GC- or LC-MS
Medchemexpress LLC Lamotrigine-d3 | 1132746-94-1 | 1 MG
Lamotrigine-d3 is the deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. It selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, among others. It is intended for research use only. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Hydralazine-d4 hydrochloride | 2749234-32-8 | 1 MG
Hydralazine-d4 hydrochloride is the deuterium labeled form of Hydralazine hydrochloride, a direct-acting vasodilator used as an antihypertensive agent. This compound incorporates stable heavy isotopes for use as tracers in drug development, where deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can serve as an internal standard for quantitative analysis through techniques such as NMR, GC-MS, or LC-MS
Medchemexpress LLC D-Glucose-d1-3 | 106032-60-4 | 99.9% | 5 MG
D-Glucose-d1-3 is the deuterium labeled D-Glucose. D-Glucose, a monosaccharide, is an important carbohydrate and critical component of general metabolism and signaling pathways.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.