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Isotopically Labeled Compounds

Chemicals to which isotopes have been attached in order to label specific atoms. Isotopically labeled compounds are commonly used in synthetic chemistry, characterization techniques such as NMR, and biology.

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1

Medchemexpress LLC Acetylcholine-d16 bromide | 347841-43-4 | 98.6% | 5 MG
SDP

Acetylcholine-d16 bromide is a deuterium-labeled form of Acetylcholine bromide, intended solely for research applications. It serves as a valuable tool in drug development, enabling its use as a tracer and internal standard for quantitative analysis in techniques such as NMR, GC-MS, or LC-MS. The incorporation of stable heavy isotopes like deuterium has been noted for its potential impact on the pharmacokinetic and metabolic profiles of drugs.

  • Deuterium labeled compound
  • Used as a tracer
  • Used as an internal standard for quantitative analysis
  • Compatible with NMR, GC-MS, or LC-MS
  • White to off-white solid
  • Soluble in water at 250 mg/mL

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2

Medchemexpress LLC Acetylcholine-d16 bromide | 347841-43-4 | 98.6% | 1 MG
SDP

Acetylcholine-d16 (bromide) is a deuterium labeled Acetylcholine bromide intended for research use. It serves as a valuable tool for quantitative analysis using techniques like NMR, GC-MS, or LC-MS, where it can act as a tracer or an internal standard.

  • Stable heavy isotopes are incorporated into drug molecules
  • Used as tracers for quantitation during drug development
  • Deuteration can affect pharmacokinetic and metabolic profiles of drugs

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3

Medchemexpress LLC Sorafenib-d3 (Donafenib; Bay 43-9006-d3) | 1130115-44-4 | 99.57% | 467.84 | 25 MG
SDP

Sorafenib-d3 (Donafenib) is a deuterated compound of Sorafenib, recognized as the first deuterium-generation tumor suppressor small molecule. Sorafenib itself is a multikinase inhibitor with IC50s of 6 nM for Raf-1, 20 nM for B-Raf, and 22 nM for VEGFR-3. This compound is intended for research use only. Potential advantages of deuterated compounds like Sorafenib-d3 include:

  • Extends the in vivo half-life.
  • Improves oral bioavailability.
  • Enhances metabolic characteristics.
  • Improves drug safety.
  • Preserves therapeutic properties.

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4

eMolecules​ Medchem Express / Acetylcholine-d16 (bromide) / 1mg / 784544309 / HY-B0282AS3 / / 347841-43-4 / MFCD01074175 / 242.212 / C7H16BrNO2

Medchem Express / Acetylcholine-d16 (bromide) / 1mg / 784544309 / HY-B0282AS3 / / 347841-43-4 / MFCD01074175 / 242.212 / C7H16BrNO2

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