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A GPR52 agonist increases cAMP concentration in CHO cells expressing human GPR52 (EC50 75 nM) selective for GPR52 over 98 other receptors ion channels and enzymes at 10 UM increases c-Fos expression in the nucleus accumbens shell to a greater extent than in the dorsomedial striatum at 30 mg/kg increases the time spent with the novel object in the novel object recognition test in rats at 3 and 10 mg/kg
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A Clk1 Clk2 and Clk4 inhibitor (IC50s 8 20 and 12 nM respectively) selective for these kinases over Clk3 (IC50 >3000 nM) as well as DYRK1A DYRK1B DYRK2 HIPK1 and HIPK3 (IC50s 213 956 1309 187 and 159 nM respectively) but does inhibit HIPK2 (IC50 23 nM)
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