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A collection of genes utilized by the RNA interference (RNAi) pathway; the RNAi pathway is a biological process in which RNA molecules inhibit gene expression or translation by neutralizing targeted mRNA molecules. Ideal for genetic screening.
The Invitrogen™ LentiArray™ Human Epigenetics Library targets 396 genes with up to 4 gRNA per gene target (pooled in a single well) for a total of 1,548 gRNAs. Libraries are delivered as 100 μL of ready to use lentiviral particles per gene target.
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The award-winning Invitrogen™ LentiArray™ Human Whole Genome Library targets 18,453 genes with up to 4 gRNA per gene target (pooled in a single well) for a total of 73,812 gRNAs.
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The award-winning Invitrogen™ LentiArray™ Human Membrane Trafficking Library targets 141 genes with up to 4 gRNA per gene target (pooled in a single well) for a total of 564 gRNAs. Libraries are delivered as 100 μL of ready to use lentiviral particles per gene target.
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These siRNA collections enable medium and high throughput analysis of phenotypes resulting from inhibition of large sets of targets from specific functional classes.
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DNA surveillance proteins monitor DNA integrity, and they can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. This can prevent potentially deleterious mutations.
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Mutations that cause a loss or reduction in gene function can result in the progression to cancer, usually in combination with other genetic changes. Tumor suppressor genes, or anti-oncogenes, can protect cells on the path to becoming cancerous.
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The Silencer™ Human Membrane Trafficking siRNA Library is designed for researchers targeting proteins known or predicted to participate in membrane trafficking or remodeling.
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