Abiraterone-d4 is a deuterium-labeled version of Abiraterone, acting as a potent, irreversible inhibitor of CYP17A1. It exhibits antiandrogen activity by inhibiting 17α-hydroxylase and 17,20-lyase activities of CYP17 (IC50 values of 2.5 nM and 15 nM, respectively). Intended for research use only, it serves as a tracer or internal standard for quantitative analysis methods like NMR, GC-MS, or LC-MS. Deuteration aids quantitation in drug development and can influence pharmacokinetic and metabolic profiles.
- Potent, irreversible CYP17A1 inhibitor
- Antiandrogen activity, inhibiting 17α-hydroxylase and 17,20-lyase activities of CYP17
- For research use only
- Tracer or internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration for quantitation in drug development and influencing pharmacokinetic profiles