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Destruxin B is a cyclodepsipeptide isolated from the entomopathogenic fungus Metarhizium anisopliae. It exhibits both insecticidal and anticancer activities. This compound induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human non-small cell lung cancer cells, significantly activating caspase-3 and reducing tumor cell proliferation.
Induces apoptosis through a Bcl-2 Family-dependent mitochondrial pathway
Activates caspase-3 in human non-small cell lung cancer cells
Reduces tumor cell proliferation both in vitro and in vivo
Inhibits cell proliferation in H1299 and A549 cells
Attenuates tumor growth in animal models
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