Patamostat (E-3123) is a potent protease inhibitor. It effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively. Patamostat may also have suppressive effects on the pathogenesis and development of acute pancreatitis.
- Effectively inhibits trypsin, plasmin, and thrombin
- May suppress pathogenesis and development of acute pancreatitis