Hs00075452_cn

• Gene Symbol: ADRA2C
• Assay Reference Genome Location: Chr.4:3766971 on build GRCh38
• Cytoband: 4p16.3

Target Gene Details

• Entrez Gene ID: 152
• Gene Name: adrenoceptor alpha 2C
• Gene Aliases: ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
• Location: Chr.4:3766569-3768526 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRA2C	NM_000683.3	1	403	NP_000674.2
	BC142625.1	1	574
	J03853.1	1	403	AAA35513.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv998670	Chr.4:3452060 - 3907808 on Build GRCh38	Gain	ADRA2C DOK7 LRPAP1 LOC100133461 LINC00955
esv26274	Chr.4:3765714 - 3768719 on Build GRCh38	Loss	ADRA2C
nsv519631	Chr.4:3752639 - 3778345 on Build GRCh38	Loss	ADRA2C
nsv593470	Chr.4:3765829 - 3768071 on Build GRCh38	Gain+Loss	ADRA2C
esv2759219	Chr.4:3392617 - 4349259 on Build GRCh38	Gain	FAM86EP HGFAC ADRA2C TMEM128 DOK7 LYAR LRPAP1 LOC100133461 OTOP1 LINC00955 ZBTB49 RGS12
nsv997647	Chr.4:3751070 - 3825288 on Build GRCh38	Gain	ADRA2C
dgv8928n54	Chr.4:3751690 - 3768342 on Build GRCh38	Loss	ADRA2C
nsv949772	Chr.4:3699474 - 3814873 on Build GRCh38	Deletion	ADRA2C
dgv8929n54	Chr.4:3766386 - 3768639 on Build GRCh38	Loss	ADRA2C
nsv593468	Chr.4:3758366 - 3767403 on Build GRCh38	Loss	ADRA2C
esv3575674	Chr.4:3635734 - 3924606 on Build GRCh38	Gain	ADRA2C LOC100133461
dgv854n67	Chr.4:3763999 - 3769080 on Build GRCh38	Gain	ADRA2C
nsv1005210	Chr.4:3711267 - 3772212 on Build GRCh38	Gain	ADRA2C

More Information

Additional Information:

For this assay, SNP(s) [rs138457504] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

G-protein coupled receptor signaling pathway
cell-cell signaling
female pregnancy
negative regulation of norepinephrine secretion
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
positive regulation of vasoconstriction
regulation of insulin secretion
regulation of sensory perception of pain
negative regulation of uterine smooth muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway

Function(s)

alpha2-adrenergic receptor activity
protein binding
alpha-2A adrenergic receptor binding
protein homodimerization activity
protein heterodimerization activity
epinephrine binding