Hs00114987_cn

• Gene Symbol: RAD51
• Assay Reference Genome Location: Chr.15:40698820 on build GRCh38
• Cytoband: 15q15.1

Target Gene Details

• Entrez Gene ID: 5888
• Gene Name: RAD51 recombinase
• Gene Aliases: BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
• Location: Chr.15:40694774-40732340 on Build GRCh38
• Assay Gene Location: Overlaps Exon 4 - Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RAD51	NM_001164269.1			NP_001157741.1
	NM_001164270.1			NP_001157742.1
	NM_002875.4			NP_002866.2
	NM_133487.3			NP_597994.3
	XM_006720626.3			XP_006720689.1
	XM_011521857.2			XP_011520159.1
	XM_011521858.2			XP_011520160.1
	XM_011521859.2			XP_011520161.1
	XM_011521860.2			XP_011520162.1
	XM_011521861.2			XP_011520163.1
	XM_011521862.2			XP_011520164.1
	AK131299.1			BAD18467.1
	AK291969.1
	AK303089.1
	AK313503.1
	AU100170.1
	BC001459.2			AAH01459.1
	BT019705.1			AAV38511.1
	CR536559.1			CAG38796.1
	D13804.1			BAA02962.1
	D14134.1			BAA03189.1
	EU362635.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2760026	Chr.15:40540346 - 40702913 on Build GRCh38	Loss	RAD51 C15orf57 KNL1 RPUSD2 RAD51-AS1
nsv832984	Chr.15:40502192 - 40706337 on Build GRCh38	Loss	MRPL42P5 RAD51 C15orf57 KNL1 RPUSD2 RAD51-AS1
nsv529030	Chr.15:40664273 - 40720497 on Build GRCh38	Loss	RAD51 KNL1 RAD51-AS1
nsv527234	Chr.15:40695527 - 40739488 on Build GRCh38	Loss	RMDN3 RAD51

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA recombinase assembly
DNA synthesis involved in DNA repair
strand displacement
regulation of protein phosphorylation
DNA unwinding involved in DNA replication
DNA repair
DNA recombination
mitotic recombination
cellular response to DNA damage stimulus
meiotic nuclear division
reciprocal meiotic recombination
response to toxic substance
response to X-ray
regulation of double-strand break repair via homologous recombination
telomere maintenance via telomere lengthening
replication fork processing
strand invasion
response to drug
positive regulation of DNA ligation
protein homooligomerization
chromosome organization involved in meiotic cell cycle
cellular response to ionizing radiation
cellular response to gamma radiation
cellular response to hydroxyurea
cellular response to cisplatin
cellular response to camptothecin
response to etoposide
replication-born double-strand break repair via sister chromatid exchange
mitotic recombination-dependent replication fork processing

Function(s)

recombinase activity
four-way junction DNA binding
chromatin binding
double-stranded DNA binding
single-stranded DNA binding
endodeoxyribonuclease activity
protein binding
ATP binding
protein C-terminus binding
identical protein binding
single-stranded DNA-dependent ATPase activity
DNA polymerase binding