Hs00189425_cn

• Gene Symbol: MAP3K12
• Assay Reference Genome Location: Chr.12:53480508 on build GRCh38
• Cytoband: 12q13.13

Target Gene Details

• Entrez Gene ID: 7786
• Gene Name: mitogen-activated protein kinase kinase kinase 12
• Gene Aliases: DLK, MEKK12, MUK, ZPK, ZPKP1
• Location: Chr.12:53480492-53501066 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 18

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MAP3K12	NM_001193511.1			NP_001180440.1
	NM_006301.3			NP_006292.3
	XM_005269138.3			XP_005269195.1
	XM_006719588.3			XP_006719651.1
	XM_011538725.2			XP_011537027.1
	XM_017019956.1			XP_016875445.1
	AB209453.1			BAD92690.1
	BC050050.1			AAH50050.1
	U07358.1			AAA67343.1

Target Gene Details

• Entrez Gene ID: 5094
• Gene Name: poly(rC) binding protein 2
• Gene Aliases: HNRNPE2, HNRPE2, hnRNP-E2
• Location: Chr.12:53452102-53481162 on Build GRCh38
• Assay Gene Location: Within Exon 15

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PCBP2	NM_001098620.2	14	2412	NP_001092090.1
	NM_001128911.1	15	2514	NP_001122383.1
	NM_001128912.1	15	2502	NP_001122384.1
	NM_001128913.1	14	2424	NP_001122385.1
	NM_001128914.1	13	2373	NP_001122386.1
	NM_005016.5	15	2517	NP_005007.2
	NM_031989.4	15	2505	NP_114366.1
	AK130583.1	7	1620
	AK225357.1	12	2087

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv714	Chr.12:53455169 - 53489159 on Build GRCh38	Insertion	MAP3K12 PCBP2-OT1 PCBP2

More Information

• Set Membership: Intragenic, Exonic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, RNA metabolism protein

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
protein phosphorylation
JNK cascade
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
intracellular signal transduction
protein autophosphorylation
mitophagy in response to mitochondrial depolarization
negative regulation of motor neuron apoptotic process
mRNA splicing, via spliceosome
gene expression
mRNA metabolic process
negative regulation of type I interferon production
viral RNA genome replication
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
negative regulation of defense response to virus
defense response to virus
IRES-dependent viral translational initiation

Function(s)

protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
protein kinase binding
protein homodimerization activity
DNA binding
RNA binding
enzyme binding
ubiquitin protein ligase binding
poly(A) RNA binding