Hs00191527_cn

• Gene Symbol: CDK2
• Assay Reference Genome Location: Chr.12:55972179 on build GRCh38
• Cytoband: 12q13.2

Target Gene Details

• Entrez Gene ID: 1017
• Gene Name: cyclin dependent kinase 2
• Gene Aliases: CDKN2, p33(CDK2)
• Location: Chr.12:55966769-55972789 on Build GRCh38
• Assay Gene Location: Within Exon 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CDK2	NM_001290230.1	5	1511	NP_001277159.1
	NM_001798.4	7	1691	NP_001789.2
	NM_052827.3	6	1589	NP_439892.2
	XM_011537732.1	8	1835	XP_011536034.1
	AA789250.1	1	613
	BC003065.2	7	1611	AAH03065.1
	M68520.1	7	1641	AAA35667.1
	X61622.1			CAA43807.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv832424	Chr.12:55881442 - 56073133 on Build GRCh38	Loss	PYM1 SUOX DGKA IKZF4 RPS26 PMEL CDK2 LOC105369781 RAB5B
nsv1051961	Chr.12:55868436 - 56235643 on Build GRCh38	Gain	LOC107987175 RPL41 MYL6 PYM1 SUOX DGKA IKZF4 ZC3H10 RPS26 RNF41 SMARCC2 PMEL CDK2 SLC39A5 ERBB3 NABP2 MYL6B ESYT1 PA2G4 LOC105369781 RAB5B

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
lens development in camera-type eye
DNA replication
DNA repair
potassium ion transport
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear division
centriole replication
meiotic nuclear division
Ras protein signal transduction
positive regulation of cell proliferation
response to toxic substance
histone phosphorylation
peptidyl-serine phosphorylation
organ regeneration
mitotic G1 DNA damage checkpoint
positive regulation of DNA-dependent DNA replication initiation
response to estradiol
cellular response to insulin stimulus
response to drug
response to ethanol
positive regulation of transcription, DNA-templated
response to cadmium ion
centrosome duplication
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
response to cAMP
response to electrical stimulus
regulation of gene silencing
cellular response to nitric oxide
regulation of signal transduction by p53 class mediator

Function(s)

protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
cyclin binding
protein complex binding
histone kinase activity
metal ion binding