Hs00257581_cn

• Gene Symbol: SLC11A1
• Assay Reference Genome Location: Chr.2:218382356 on build GRCh38
• Cytoband: 2q35

Target Gene Details

• Entrez Gene ID: 6556
• Gene Name: solute carrier family 11 member 1
• Gene Aliases: LSH, NRAMP, NRAMP1
• Location: Chr.2:218381766-218396894 on Build GRCh38
• Assay Gene Location: Overlaps Exon 1 - Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SLC11A1	NM_000578.3			NP_000569.3
	XM_005246793.3			XP_005246850.1
	XM_005246794.3			XP_005246851.1
	XM_006712709.3			XP_006712772.1
	XM_006712710.3			XP_006712773.1
	XM_006712711.3			XP_006712774.1
	XM_011511684.2			XP_011509986.1
	XM_011511685.2			XP_011509987.1
	XM_017004765.1			XP_016860254.1
	XM_017004766.1			XP_016860255.1
	XM_017004767.1			XP_016860256.1
	AB209650.1			BAD92887.1
	AK294707.1
	AK298667.1
	AK303398.1
	AK307954.1
	AK310914.1
	AK311405.1
	D50402.1			BAA08907.1
	D50403.1			BAA08908.1
	DB284801.1
	L32185.1			AAA57521.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv519829	Chr.2:218286495 - 218403058 on Build GRCh38	Loss	CATIP-AS1 TMBIM1 CATIP-AS2 SLC11A1 CATIP CTDSP1 MIR6810 PNKD MIR26B
nsv3166	Chr.2:218371765 - 218405183 on Build GRCh38	Insertion	SLC11A1 CTDSP1 MIR26B

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

secondary carrier transporter

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
negative regulation of cytokine production
positive regulation of cytokine production
T cell proliferation involved in immune response
T cell cytokine production
positive regulation of dendritic cell antigen processing and presentation
positive regulation of T-helper 1 type immune response
iron ion transport
manganese ion transport
cellular cadmium ion homeostasis
cellular iron ion homeostasis
phagocytosis
inflammatory response
vacuolar acidification
response to bacterium
positive regulation of gene expression
nitrite transport
activation of protein kinase activity
response to lipopolysaccharide
interleukin-2 production
interleukin-3 production
positive regulation of interferon-gamma production
response to interferon-gamma
wound healing
macrophage activation
defense response to bacterium
defense response to protozoan
L-arginine import
MHC class II biosynthetic process
cell redox homeostasis
respiratory burst
positive regulation of transcription from RNA polymerase II promoter
antigen processing and presentation of peptide antigen
mRNA stabilization
positive regulation of phagocytosis
defense response to Gram-negative bacterium
iron ion homeostasis
multicellular organismal iron ion homeostasis
cadmium ion transmembrane transport
divalent metal ion export
manganese ion transmembrane transport

Function(s)

manganese ion transmembrane transporter activity
protein homodimerization activity
transition metal ion transmembrane transporter activity
metal ion:proton antiporter activity