Hs00258036_cn

• Gene Symbol: TPPP
• Assay Reference Genome Location: Chr.5:665138 on build GRCh38
• Cytoband: 5p15.33

Target Gene Details

• Entrez Gene ID: 11076
• Gene Name: tubulin polymerization promoting protein
• Gene Aliases: TPPP/p25, TPPP1, p24, p25, p25alpha
• Location: Chr.5:659862-730454 on Build GRCh38
• Assay Gene Location: Within Exon 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TPPP	NM_007030.2	4	746	NP_008961.1
	XM_005248237.3	4	811	XP_005248294.2
	XM_017008993.1	4	2942	XP_016864482.1
	XM_017008994.1	6	797	XP_016864483.1
	AB017016.1	4	657	BAA36164.1
	AK054920.1	3	1343
	AK098392.1	4	702
	AY319261.1	3	624	AAQ96657.1
	BC040496.1	4	670	AAH40496.1
	BC131506.1	3	642
	BC152382.1	3	627
	BT020035.1	3	624	AAV38838.1
	DB478250.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv5521n100	Chr.5:568570 - 685633 on Build GRCh38	Gain	CEP72 LOC101929895 TPPP LOC100996325
esv3894107	Chr.5:81322 - 801057 on Build GRCh38	Gain	PDCD6 LOC100288152 ZDHHC11 MIR4456 CCDC127 PP7080 SDHA HRAT5 LRRC14B AHRR CEP72 EXOC3 LOC101929895 TPPP LOC100996325 ZDHHC11B SLC9A3 PLEKHG4B EXOC3-AS1
nsv4675	Chr.5:658779 - 844631 on Build GRCh38	Deletion	ZDHHC11 CEP72 LOC101929895 TPPP ZDHHC11B
nsv1032584	Chr.5:375290 - 809679 on Build GRCh38	Gain	LOC100288152 ZDHHC11 MIR4456 PP7080 AHRR CEP72 EXOC3 LOC101929895 TPPP LOC100996325 ZDHHC11B SLC9A3 EXOC3-AS1
esv2759316	Chr.5:620048 - 1161361 on Build GRCh38	Gain+Loss	LOC100506688 ZDHHC11 CEP72 TRIP13 LOC101929895 TPPP BRD9 ZDHHC11B NKD2 MIR4635 SLC12A7
dgv7n29	Chr.5:609831 - 820394 on Build GRCh38	Gain	ZDHHC11 CEP72 LOC101929895 TPPP LOC100996325 ZDHHC11B
nsv1033593	Chr.5:609765 - 685633 on Build GRCh38	Gain	CEP72 LOC101929895 TPPP LOC100996325
nsv596703	Chr.5:539195 - 685633 on Build GRCh38	Gain	CEP72 LOC101929895 TPPP LOC100996325
nsv596629	Chr.5:457146 - 1468172 on Build GRCh38	Gain	LOC100288152 ZDHHC11 CLPTM1L MIR4456 TERT PP7080 SLC6A18 TRIP13 LOC101929895 TPPP LOC100996325 ZDHHC11B NKD2 MIR4635 SLC12A7 CTD-3080P12.3 LOC100506688 BRD9 LPCAT1 LINC01511 CEP72 EXOC3 SLC6A19 SLC9A3 MIR4457 SLC6A3
nsv471627	Chr.5:609832 - 826405 on Build GRCh38	Gain+Loss	ZDHHC11 CEP72 LOC101929895 TPPP LOC100996325 ZDHHC11B
nsv509042	Chr.5:483833 - 720373 on Build GRCh38	Insertion	CEP72 LOC101929895 MIR4456 TPPP LOC100996325 ZDHHC11B SLC9A3
nsv950622	Chr.5:661486 - 693585 on Build GRCh38	Deletion	CEP72 LOC101929895 TPPP
nsv1161198	Chr.5:654181 - 817735 on Build GRCh38	Duplication	ZDHHC11 CEP72 LOC101929895 TPPP ZDHHC11B
esv3575804	Chr.5:588315 - 676732 on Build GRCh38	Gain	CEP72 LOC101929895 TPPP LOC100996325
dgv922n67	Chr.5:662068 - 788975 on Build GRCh38	Gain	CEP72 LOC101929895 TPPP ZDHHC11B
dgv195e55	Chr.5:659490 - 823705 on Build GRCh38	Gain	ZDHHC11 CEP72 LOC101929895 TPPP ZDHHC11B
dgv5522n100	Chr.5:625176 - 809679 on Build GRCh38	Gain	ZDHHC11 CEP72 LOC101929895 TPPP ZDHHC11B
nsv596710	Chr.5:595755 - 729907 on Build GRCh38	Gain	CEP72 LOC101929895 TPPP LOC100996325 ZDHHC11B
dgv131e203	Chr.5:653466 - 874903 on Build GRCh38	Gain+Loss	ZDHHC11 CEP72 LOC101929895 TPPP BRD9 ZDHHC11B
esv2752071	Chr.5:378298 - 699075 on Build GRCh38	Gain	AHRR LOC100288152 CEP72 EXOC3 LOC101929895 MIR4456 TPPP LOC100996325 PP7080 SLC9A3 EXOC3-AS1
dgv5524n100	Chr.5:659283 - 825526 on Build GRCh38	Gain	ZDHHC11 CEP72 LOC101929895 TPPP ZDHHC11B
dgv5523n100	Chr.5:653454 - 790474 on Build GRCh38	Gain	CEP72 LOC101929895 TPPP ZDHHC11B
nsv461894	Chr.5:593968 - 685633 on Build GRCh38	Gain	CEP72 LOC101929895 TPPP LOC100996325

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

non-motor microtubule binding protein

Gene Ontology Categories:

Process(es)

microtubule bundle formation
positive regulation of protein complex assembly
positive regulation of protein polymerization
microtubule polymerization

Function(s)

protein binding
microtubule binding
tubulin binding