Hs00282691_cn

• Gene Symbol: ADRB1
• Assay Reference Genome Location: Chr.10:114044412 on build GRCh38
• Cytoband: 10q25.3

Target Gene Details

• Entrez Gene ID: 153
• Gene Name: adrenoceptor beta 1
• Gene Aliases: ADRB1R, B1AR, BETA1AR, RHR
• Location: Chr.10:114044047-114046908 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADRB1	NM_000684.2	1	366	NP_000675.1
	J03019.1	1	366	AAA51667.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951851	Chr.10:114043342 - 114045341 on Build GRCh38	Deletion	ADRB1
nsv552203	Chr.10:114041494 - 114047023 on Build GRCh38	Loss	ADRB1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

temperature homeostasis
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of the force of heart contraction by epinephrine-norepinephrine
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
activation of adenylate cyclase activity
cell-cell signaling
response to cold
positive regulation of cAMP biosynthetic process
heat generation
negative regulation of multicellular organism growth
fear response
positive regulation of GTPase activity
positive regulation of cAMP-mediated signaling
brown fat cell differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway

Function(s)

beta-adrenergic receptor activity
beta1-adrenergic receptor activity
receptor signaling protein activity
Ras guanyl-nucleotide exchange factor activity
protein binding
PDZ domain binding
alpha-2A adrenergic receptor binding
protein heterodimerization activity
epinephrine binding
norepinephrine binding