Hs00298001_cn

• Gene Symbol: FOXO3
• Assay Reference Genome Location: Chr.6:108560010 on build GRCh38
• Cytoband: 6q21

Target Gene Details

• Entrez Gene ID: 2309
• Gene Name: forkhead box O3
• Gene Aliases: AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
• Location: Chr.6:108559823-108684769 on Build GRCh38
• Assay Gene Location: Overlaps Exon 1 - Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FOXO3	NM_201559.2			NP_963853.1
	BC020227.1			AAH20227.1
	BC021224.2			AAH21224.1
	CD101760.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv10904n54	Chr.6:108559308 - 108561930 on Build GRCh38	Loss	FOXO3
nsv823817	Chr.6:108556562 - 108562652 on Build GRCh38	Gain	FOXO3
nsv604482	Chr.6:108559788 - 108561930 on Build GRCh38	Gain	FOXO3
nsv604476	Chr.6:108556849 - 108561930 on Build GRCh38	Gain	FOXO3
nsv1017621	Chr.6:108524796 - 108569702 on Build GRCh38	Gain	FOXO3 LACE1
nsv830767	Chr.6:108476568 - 108667716 on Build GRCh38	Gain	FOXO3 LACE1
esv22566	Chr.6:108557767 - 108562009 on Build GRCh38	Loss	FOXO3
nsv604477	Chr.6:108558488 - 108561930 on Build GRCh38	Gain	FOXO3

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
initiation of primordial ovarian follicle growth
antral ovarian follicle growth
oocyte maturation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of translation
DNA damage response, signal transduction by p53 class mediator
tumor necrosis factor-mediated signaling pathway
cellular response to oxidative stress
glucose homeostasis
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neural precursor cell proliferation
regulation of reactive oxygen species metabolic process

Function(s)

core promoter binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase binding
chromatin DNA binding
sequence-specific DNA binding