Hs00418088_cn

• Gene Symbol: ACOT8
• Assay Reference Genome Location: Chr.20:45842458 on build GRCh38
• Cytoband: 20q13.12

Target Gene Details

• Entrez Gene ID: 10005
• Gene Name: acyl-CoA thioesterase 8
• Gene Aliases: HNAACTE, NAP1, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE
• Location: Chr.20:45841721-45857409 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ACOT8	NM_005469.3			NP_005460.2
	XM_005260239.3			XP_005260296.1
	XM_011528480.2			XP_011526782.1
	AF014404.1			AAB71665.1
	AF124264.1			AAD27616.1
	AK056668.1	3	2371
	AK126206.1	2	2624
	BC117155.1
	BC117157.1
	BM986979.1
	CR541771.1			CAG46570.1
	CR541778.1			CAG46577.1
	X86032.1			CAA60024.1

Target Gene Details

• Entrez Gene ID: 90203
• Gene Name: sorting nexin family member 21
• Gene Aliases: C20orf161, PP3993, SNX-L, dJ337O18.4
• Location: Chr.20:45833418-45843275 on Build GRCh38
• Assay Gene Location: Within Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SNX21	NM_001042632.2	4	2349	NP_001036097.1
	NM_001042633.2	5	2367	NP_001036098.1
	NM_033421.3	4	2356	NP_219489.1
	NM_152897.2	5	1104	NP_690857.1
	XM_005260608.4	2	2431	XP_005260665.1
	XM_011529095.2	2	2335	XP_011527397.1
	AF258570.1			AAG23773.1
	AK091359.1	3	2371	BAC03646.1
	AK095851.1	3	2230	BAC04637.1
	BC019823.1	5	1077	AAH19823.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833990	Chr.20:45771510 - 45946844 on Build GRCh38	Loss	PCIF1 PLTP WFDC3 NEURL2 DNTTIP1 SNX21 TNNC2 ZSWIM3 UBE2C SPATA25 LOC107985388 CTSA ACOT8 ZSWIM1
nsv586132	Chr.20:45785138 - 45842587 on Build GRCh38	Loss	WFDC3 DNTTIP1 SNX21 TNNC2 ACOT8 UBE2C

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

esterase, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

acyl-CoA metabolic process
bile acid biosynthetic process
viral process
peroxisome fission
fatty acid beta-oxidation using acyl-CoA oxidase
long-chain fatty-acyl-CoA biosynthetic process
alpha-linolenic acid metabolic process
dicarboxylic acid catabolic process
negative regulation of CD4 biosynthetic process
protein transport

Function(s)

acetyl-CoA hydrolase activity
receptor binding
protein binding
CoA hydrolase activity
palmitoyl-CoA hydrolase activity
choloyl-CoA hydrolase activity
acyl-CoA hydrolase activity
carboxylic ester hydrolase activity
medium-chain acyl-CoA hydrolase activity
long-chain acyl-CoA hydrolase activity
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding