Hs00441245_cn

• Gene Symbol: PTPA
• Assay Reference Genome Location: Chr.9:129111068 on build GRCh38
• Cytoband: 9q34.11

Target Gene Details

• Entrez Gene ID: 5524
• Gene Name: protein phosphatase 2 phosphatase activator
• Gene Aliases: PP2A, PPP2R4, PR53
• Location: Chr.9:129110949-129148946 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTPA	NM_021131.4			NP_066954.2
	XM_011518834.2			XP_011517136.1
	XM_011518836.2			XP_011517138.1
	XM_011518838.2			XP_011517140.1
	BC002545.2			AAH02545.1
	BC011605.2			AAH11605.1
	DB009663.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv818725	Chr.9:129026890 - 129176634 on Build GRCh38	Gain	DOLPP1 CRAT IER5L SH3GLB2 MIGA2 PTPA
nsv831729	Chr.9:128973042 - 129158330 on Build GRCh38	Loss	DOLPP1 CRAT SH3GLB2 MIGA2 PTPA NUP188
nsv509323	Chr.9:128991062 - 129129399 on Build GRCh38	Insertion	DOLPP1 CRAT SH3GLB2 MIGA2 PTPA NUP188

More Information

Additional Information:

For this assay, SNP(s) [rs76817874] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, phosphatase activator, phosphatase modulator

Gene Ontology Categories:

Process(es)

protein peptidyl-prolyl isomerization
mitotic spindle organization in nucleus
negative regulation of phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity
regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
negative regulation of protein dephosphorylation
positive regulation of apoptotic process
regulation of phosphoprotein phosphatase activity

Function(s)

peptidyl-prolyl cis-trans isomerase activity
receptor binding
protein binding
ATP binding
protein tyrosine phosphatase activator activity
protein phosphatase type 2A regulator activity
ATPase activity
protein homodimerization activity
protein heterodimerization activity
protein phosphatase 2A binding