Hs00493939_cn

• Gene Symbol: PSMB4
• Assay Reference Genome Location: Chr.1:151399726 on build GRCh38
• Cytoband: 1q21.3

Target Gene Details

• Entrez Gene ID: 5692
• Gene Name: proteasome subunit beta 4
• Gene Aliases: HN3, HsN3, PROS-26, PROS26
• Location: Chr.1:151399565-151401936 on Build GRCh38
• Assay Gene Location: Overlaps Exon 1 - Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PSMB4	NM_002796.2			NP_002787.2
	AK294149.1
	AK313825.1
	BT006917.1			AAP35563.1
	CR456820.1			CAG33101.1
	D26600.1			BAA05647.1
	S71381.1			AAB31085.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv824575	Chr.1:151359057 - 151435620 on Build GRCh38	Gain	SELENBP1 PSMB4 POGZ
esv3890638	Chr.1:151398829 - 151435216 on Build GRCh38	Gain	PSMB4 POGZ
dgv53e214	Chr.1:151359619 - 151441151 on Build GRCh38	Gain	SELENBP1 PSMB4 POGZ
nsv1161560	Chr.1:151359541 - 151436260 on Build GRCh38	Duplication	SELENBP1 PSMB4 POGZ
nsv8380	Chr.1:151357411 - 151437870 on Build GRCh38	Gain	SELENBP1 PSMB4 POGZ
esv34461	Chr.1:151268066 - 151439159 on Build GRCh38	Gain	ZNF687 LOC100507670 GBAT2 RFX5 SELENBP1 PSMB4 PI4KB POGZ
dgv36n27	Chr.1:151360691 - 151440704 on Build GRCh38	Gain	SELENBP1 PSMB4 POGZ
nsv441714	Chr.1:151364223 - 151425402 on Build GRCh38	Gain	SELENBP1 PSMB4 POGZ
nsv831581	Chr.1:151316675 - 151506129 on Build GRCh38	Loss	GBAT2 RFX5 SELENBP1 PSMB4 PI4KB POGZ
esv3587526	Chr.1:151360740 - 151441151 on Build GRCh38	Loss	SELENBP1 PSMB4 POGZ
esv3587525	Chr.1:151360256 - 151412906 on Build GRCh38	Gain	SELENBP1 PSMB4 POGZ
esv2758969	Chr.1:151356318 - 151439159 on Build GRCh38	Gain	SELENBP1 PSMB4 POGZ

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
negative regulation of inflammatory response to antigenic stimulus
regulation of cellular amino acid metabolic process
viral process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway

Function(s)

lipopolysaccharide binding
threonine-type endopeptidase activity
protein binding