Hs00526336_cn

• Gene Symbol: NFATC4
• Assay Reference Genome Location: Chr.14:24372521 on build GRCh38
• Cytoband: 14q12

Target Gene Details

• Entrez Gene ID: 4776
• Gene Name: nuclear factor of activated T-cells 4
• Gene Aliases: NF-AT3, NF-ATC4, NFAT3
• Location: Chr.14:24366911-24379604 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NFATC4	NM_001136022.2	4	1610	NP_001129494.1
	NM_001198965.1	3	1598	NP_001185894.1
	NM_001198966.2	3	1252	NP_001185895.1
	NM_001198967.2	4	1610	NP_001185896.1
	NM_001288802.1	3	1401	NP_001275731.1
	NM_001320043.1	4	1610	NP_001306972.1
	NM_004554.4	3	1598	NP_004545.2
	XM_011536797.2	3	1433	XP_011535099.1
	XM_011536798.1	3	1523	XP_011535100.1
	XM_011536799.2	3	1435	XP_011535101.1
	AK293185.1	3	1473
	AK300450.1	3	1276
	AK302271.1	3	1238
	AK309339.1	4	1398
	AK310433.1	3	1401
	AK310445.1	4	1582
	AK311078.1	3	508
	AK311425.1	3	626
	BC008857.2	2	1099	AAH08857.2
	BC053855.1	3	1414	AAH53855.1
	EU887632.1	4	1582
	EU887633.1	4	1582
	EU887634.1	4	1582
	EU887635.1	4	1398
	EU887636.1	4	1398
	EU887637.1	4	1398
	EU887638.1	4	1451
	EU887639.1	4	1451
	EU887640.1	4	1451
	EU887641.1	3	1277
	EU887642.1	3	1277
	EU887643.1	3	1277
	EU887644.1	3	1401
	EU887645.1	3	1401
	EU887646.1	3	1401
	EU887647.1	2	1523
	EU887648.1	2	1523
	EU887649.1	2	1523
	L41066.1	3	1418	AAA79175.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv952819	Chr.14:24367695 - 24377694 on Build GRCh38	Deletion	NFATC4

More Information

Additional Information:

For this assay, SNP(s) [rs559109128] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

Rel homology transcription factor

Gene Ontology Categories:

Process(es)

patterning of blood vessels
transcription from RNA polymerase II promoter
inflammatory response
heart development
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of Wnt signaling pathway
negative regulation of protein binding
positive regulation of tumor necrosis factor production
calcineurin-NFAT signaling cascade
cellular response to UV
negative regulation of chromatin binding
cellular respiration
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
negative regulation of dendrite morphogenesis
smooth muscle cell differentiation
muscle cell development
cellular response to lithium ion
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of synapse maturation
positive regulation of apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
peroxisome proliferator activated receptor binding