Hs00533208_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67193478 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Overlaps Intron 3 - Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	FHOD1 NUTF2 HSF4 THAP11 PSMB10 DUS2 TRADD LOC107984813 PLEKHG4 LRRC36 PSKH1 TSNAXIP1 LOC100505942 EDC4 CTRL CARMIL2 CENPT FAM65A MIR328 LCAT HSD11B2 TMEM208 TPPP3 CTCF ACD ELMO3 LRRC29 EXOC3L1 FBXL8 RANBP10 LOC100131303 SLC12A4 C16orf86 E2F4 ENKD1 LOC105369155 DPEP3 GFOD2 ATP6V0D1 NOL3 NRN1L SLC9A5 KIAA0895L AGRP DPEP2 ZDHHC1 PARD6A DDX28 KCTD19
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	ELMO3 FHOD1 LRRC29 NOL3 EXOC3L1 HSF4 FBXL8 SLC9A5 TRADD PLEKHG4 C16orf70 E2F4 KIAA0895L MIR328 B3GNT9 LOC105369155 TMEM208
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	ELMO3 FHOD1 LRRC29 NOL3 EXOC3L1 HSF4 FBXL8 TRADD C16orf70 E2F4 KIAA0895L MIR328 B3GNT9 LOC105369155 TMEM208
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	ELMO3 LRRC29 NOL3 EXOC3L1 E2F4 KIAA0895L MIR328 HSF4 LOC105369155 FBXL8
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	ELMO3 FHOD1 LRRC29 EXOC3L1 PLEKHG4 E2F4 KIAA0895L MIR328 LOC105369155 TMEM208 SLC9A5
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	ELMO3 FHOD1 LRRC29 NOL3 EXOC3L1 SLC9A5 PLEKHG4 E2F4 KIAA0895L MIR328 LOC105369155 TMEM208 KCTD19
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	FHOD1 NUTF2 HSF4 THAP11 PSMB10 DUS2 TRADD LOC107984813 PLEKHG4 LRRC36 C16orf70 PSKH1 TSNAXIP1 LOC100505942 EDC4 CTRL CARMIL2 CENPT FAM65A MIR328 LCAT HSD11B2 TMEM208 TPPP3 CTCF ACD ELMO3 LRRC29 EXOC3L1 FBXL8 RANBP10 LOC100131303 SLC12A4 C16orf86 E2F4 ENKD1 LOC105369155 DPEP3 GFOD2 ATP6V0D1 NOL3 NRN1L SLC9A5 KIAA0895L B3GNT9 AGRP DPEP2 ZDHHC1 PARD6A DDX28 KCTD19

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding