Hs00539059_cn

• Gene Symbol: CDKN1A
• Assay Reference Genome Location: Chr.6:36678948 on build GRCh38
• Cytoband: 6p21.2

Target Gene Details

• Entrez Gene ID: 1026
• Gene Name: cyclin dependent kinase inhibitor 1A
• Gene Aliases: CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
• Location: Chr.6:36676460-36687339 on Build GRCh38
• Assay Gene Location: Overlaps Exon 4 - Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CDKN1A	NM_000389.4			NP_000380.1
	NM_001220777.1			NP_001207706.1
	NM_001220778.1			NP_001207707.1
	NM_001291549.1			NP_001278478.1
	NM_078467.2			NP_510867.1
	AB209881.1			BAD93118.1
	AK298901.1
	AK309512.1
	BC000275.1			AAH00275.1
	BC000312.2			AAH00312.1
	BC001935.1			AAH01935.1
	BC013967.2			AAH13967.1
	BU154329.1
	BU193165.1
	DA552678.1
	DA582789.1
	DA699672.1
	DA702185.1
	DA838987.1
	L25610.1			AAA16109.1
	L26165.1			AAA19811.1
	L47232.1			AAB59559.1
	L47233.1			AAB59560.1
	S67388.1			AAB29246.1
	U03106.1			AAC04313.1
	U09579.1			AAA85641.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1015689	Chr.6:36550916 - 39052434 on Build GRCh38	Gain	GLP1R ZFAND3 RAB44 TMEM217 LOC100131047 FGD2 PPIL1 PI16 CMTR1 MIR3925 CCDC167 LOC107986531 MTCH1 RNF8 DNAH8 MDGA1 PIM1 LOC100505530 GLO1 CDKN1A BTBD9 TBC1D22B MIR4462 SRSF3 C6orf89 CPNE5 PANDAR

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, kinase inhibitor, kinase modulator

Gene Ontology Categories:

Process(es)

regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle arrest
Ras protein signal transduction
negative regulation of cell proliferation
response to toxic substance
response to X-ray
response to organonitrogen compound
negative regulation of gene expression
negative regulation of cell growth
positive regulation of B cell proliferation
organ regeneration
cellular response to extracellular stimulus
regulation of protein import into nucleus, translocation
cellular response to amino acid starvation
cellular response to heat
negative regulation of phosphorylation
response to drug
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of cyclin-dependent protein serine/threonine kinase activity
response to arsenic-containing substance
positive regulation of fibroblast proliferation
protein stabilization
response to corticosterone
response to hyperoxia
intestinal epithelial cell maturation
cellular response to ionizing radiation
cellular response to UV-B
mitotic cell cycle arrest
cellular senescence
replicative senescence
stress-induced premature senescence
intrinsic apoptotic signaling pathway
positive regulation of cyclin-dependent protein kinase activity
negative regulation of G1/S transition of mitotic cell cycle
regulation of DNA biosynthetic process
positive regulation of reactive oxygen species metabolic process

Function(s)

cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
cyclin-dependent protein kinase activating kinase activity
cyclin binding
ubiquitin protein ligase binding
protein complex binding
metal ion binding