Hs00562307_cn

• Gene Symbol: ALKBH4
• Assay Reference Genome Location: Chr.7:102457530 on build GRCh38
• Cytoband: 7q22.1

Target Gene Details

• Entrez Gene ID: 54784
• Gene Name: alkB homolog 4, lysine demethylase
• Gene Aliases: ABH4
• Location: Chr.7:102456220-102464874 on Build GRCh38
• Assay Gene Location: Within Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALKBH4	NM_017621.3	3	811	NP_060091.1
	XM_005250464.2	3	704	XP_005250521.1
	XM_005250465.2	3	790	XP_005250522.1
	AK000020.1	3	798	BAA90888.1
	AK026097.1	3	709	BAB15358.1
	AK222689.1	3	800	BAD96409.1
	BC002820.2	3	778	AAH02820.1
	BC017096.1	3	778	AAH17096.1
	BX353099.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv831083	Chr.7:102340560 - 102655422 on Build GRCh38	Loss	LOC100630923 MIR4467 MIR548O ORAI2 RASA4 POLR2J2 POLR2J POLR2J3 RASA4B SPDYE2B SPDYE6 SPDYE2 MIR5090 ALKBH4 LOC107983993 LOC100289561 LRWD1 PRKRIP1 UPK3BL LOC102724229
nsv8192	Chr.7:102450605 - 102692752 on Build GRCh38	Gain	MIR4467 ORAI2 RASA4 POLR2J2 POLR2J POLR2J3 RASA4B SPDYE2B SPDYE2 MIR5090 ALKBH4 LOC107983993 LRWD1 UPK3BL LOC102724229
nsv428182	Chr.7:102257460 - 102735503 on Build GRCh38	Gain	LOC100630923 MIR4467 MIR548O ORAI2 RASA4 POLR2J2 POLR2J POLR2J3 RASA4B SPDYE2B SPDYE6 SH2B2 SPDYE2 FBXL13 MIR5090 ALKBH4 MIR4285 CUX1 LOC107983993 LOC100289561 LRWD1 PRKRIP1 UPK3BL LOC102724229
dgv6538n100	Chr.7:102171110 - 103063688 on Build GRCh38	Gain	MIR548O ORAI2 RASA4 FAM185A RASA4B SPDYE2 MIR4285 LOC100289561 PRKRIP1 LRRC17 LOC100630923 MIR4467 POLR2J2 POLR2J POLR2J3 SPDYE2B SPDYE6 SH2B2 FBXL13 MIR5090 NFE4 ALKBH4 CUX1 LOC107983993 LRWD1 UPK3BL LOC102724229
nsv607998	Chr.7:102385213 - 102473462 on Build GRCh38	Gain+Loss	LOC100630923 MIR4467 MIR548O ORAI2 MIR5090 ALKBH4 POLR2J LRWD1 PRKRIP1
nsv5879	Chr.7:102450321 - 102747356 on Build GRCh38	Deletion	MIR4467 ORAI2 RASA4 POLR2J2 POLR2J POLR2J3 RASA4B SPDYE2B SPDYE2 FBXL13 MIR5090 ALKBH4 LOC107983993 LRWD1 UPK3BL LOC102724229
nsv607999	Chr.7:102451288 - 102473452 on Build GRCh38	Loss	MIR4467 ORAI2 MIR5090 ALKBH4 POLR2J LRWD1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidoreductase, oxygenase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
regulation of transcription, DNA-templated
protein demethylation
actomyosin structure organization
cleavage furrow ingression
oxidation-reduction process

Function(s)

actin binding
protein binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
demethylase activity
metal ion binding