Hs00606579_cn

• Gene Symbol: NRG4
• Assay Reference Genome Location: Chr.15:75961922 on build GRCh38
• Cytoband: 15q24.2

Target Gene Details

• Entrez Gene ID: 145957
• Gene Name: neuregulin 4
• Gene Aliases: HRG4
• Location: Chr.15:75935190-76062997 on Build GRCh38
• Assay Gene Location: Within Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NRG4	NM_138573.3	4	339	NP_612640.1
	XM_017021937.1	8	850	XP_016877426.1
	XM_017021938.1	7	3057	XP_016877427.1
	XM_017021939.1	7	619	XP_016877428.1
	XM_017021940.1	6	3395	XP_016877429.1
	XM_017021941.1	4	358	XP_016877430.1
	XM_017021942.1	4	376	XP_016877431.1
	XM_017021943.1	4	449	XP_016877432.1
	XM_017021944.1	7	3442	XP_016877433.1
	XM_017021945.1	7	3434	XP_016877434.1
	XM_017021946.1	7	3434	XP_016877435.1
	XM_017021947.1	7	3434	XP_016877436.1
	XM_017021948.1	5	3167	XP_016877437.1
	AK307362.1	4	317
	AK311204.1	9	671
	AK311507.1	5	441
	AM392364.1	2	157	CAL35829.1
	BC017568.1	4	343	AAH17568.1
	BX538100.1	5	369	CAD98015.1
	CR749519.1	6	513	CAH18333.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2749895	Chr.15:75415580 - 76472296 on Build GRCh38	Deletion	DNM1P35 NRG4 SNUPN UBE2Q2 ODF3L1 TYRO3P LOC101929439 SNX33 FBXO22 LOC107984799 SIN3A LOC441728 CSPG4 ISL2 IMP3 ETFA MIR4313 SCAPER PTPN9 FBXO22-AS1 TMEM266
nsv569998	Chr.15:75940264 - 76258597 on Build GRCh38	Gain	NRG4 ETFA TMEM266 LOC101929439
esv3636933	Chr.15:75908231 - 76025938 on Build GRCh38	Gain	NRG4 FBXO22-AS1 FBXO22
esv2749898	Chr.15:75764003 - 77933523 on Build GRCh38	Deletion	NRG4 TSPAN3 HMG20A UBE2Q2 LOC101929457 TYRO3P LINGO1-AS2 LOC101929439 LINGO1 FBXO22 RCN2 LINC00597 LOC441728 ISL2 LINGO1-AS1 PSTPIP1 MIR3713 PEAK1 ETFA SCAPER FBXO22-AS1 TMEM266 LOC645752
dgv2622n100	Chr.15:75904333 - 76022201 on Build GRCh38	Gain	NRG4 FBXO22-AS1 FBXO22

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

MAPK cascade
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
intracellular signal transduction
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
animal organ development
regulation of cell motility

Function(s)

protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
protein binding
growth factor activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity