Hs00704377_cn

• Gene Symbol: PPME1
• Assay Reference Genome Location: Chr.11:74203766 on build GRCh38
• Cytoband: 11q13.4

Target Gene Details

• Entrez Gene ID: 51400
• Gene Name: protein phosphatase methylesterase 1
• Gene Aliases: PME-1
• Location: Chr.11:74170891-74254703 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PPME1	NM_001271593.1	2	499	NP_001258522.1
	NM_016147.2	2	499	NP_057231.1
	XM_017017913.1	2	671	XP_016873402.1
	AF157028.1	2	239	AAD44976.1
	AK001381.1	2	235	BAA91661.1
	AK022725.1	2	309
	AK225647.1	2	240
	BC003046.1	2	250	AAH03046.1
	BC050705.2	2	246	AAH50705.1
	DA691258.1	2	324
	DA824678.1	2	499

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522994	Chr.11:74195879 - 74206145 on Build GRCh38	Loss	PPME1
esv34979	Chr.11:74167643 - 74822407 on Build GRCh38	Gain	MIR4696 POLD3 LOC100287896 RNF169 MIR548AL CHRDL2 LIPT2 P4HA3 PGM2L1 LOC101928580 PPME1 KCNE3 C2CD3
esv2759837	Chr.11:74131564 - 74846552 on Build GRCh38	Gain	MIR4696 POLD3 LOC100287896 RNF169 MIR548AL CHRDL2 LIPT2 P4HA3 PGM2L1 LOC101928580 PPME1 KCNE3 XRRA1 C2CD3

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

protein modifying enzyme

Gene Ontology Categories:

Process(es)

protein demethylation
regulation of protein phosphatase type 2A activity
negative regulation of catalytic activity
cell-cell adhesion

Function(s)

protein phosphatase inhibitor activity
protein phosphatase type 2A regulator activity
protein kinase binding
protein phosphatase binding
protein phosphatase 2A binding
protein C-terminal methylesterase activity
cadherin binding involved in cell-cell adhesion