Hs00858233_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67194734 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Overlaps Intron 5 - Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	TSNAXIP1 CTRL LOC100131303 FBXL8 LRRC36 SLC12A4 DPEP2 NUTF2 HSD11B2 PSKH1 EDC4 ZDHHC1 C16orf86 TMEM208 RANBP10 DDX28 HSF4 PSMB10 LOC105369155 DPEP3 LOC100505942 ACD LCAT CARMIL2 PARD6A MIR328 CENPT ELMO3 LRRC29 CTCF FHOD1 LOC107984813 THAP11 TRADD TPPP3 KCTD19 FAM65A GFOD2 DUS2 KIAA0895L AGRP NRN1L NOL3 PLEKHG4 E2F4 ATP6V0D1 EXOC3L1 SLC9A5 ENKD1
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	HSF4 NOL3 LOC105369155 TRADD FBXL8 PLEKHG4 E2F4 EXOC3L1 MIR328 ELMO3 SLC9A5 C16orf70 B3GNT9 LRRC29 TMEM208 KIAA0895L FHOD1
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	HSF4 NOL3 LOC105369155 TRADD FBXL8 E2F4 EXOC3L1 MIR328 ELMO3 C16orf70 B3GNT9 LRRC29 TMEM208 KIAA0895L FHOD1
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	MIR328 HSF4 ELMO3 NOL3 LOC105369155 FBXL8 LRRC29 E2F4 EXOC3L1 KIAA0895L
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	MIR328 ELMO3 SLC9A5 LOC105369155 LRRC29 PLEKHG4 E2F4 TMEM208 EXOC3L1 KIAA0895L FHOD1
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	NOL3 LOC105369155 PLEKHG4 E2F4 EXOC3L1 KCTD19 MIR328 ELMO3 SLC9A5 LRRC29 TMEM208 KIAA0895L FHOD1
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	TSNAXIP1 CTRL LOC100131303 FBXL8 LRRC36 SLC12A4 DPEP2 NUTF2 HSD11B2 PSKH1 C16orf70 EDC4 ZDHHC1 C16orf86 TMEM208 RANBP10 DDX28 HSF4 PSMB10 LOC105369155 DPEP3 LOC100505942 ACD LCAT CARMIL2 PARD6A MIR328 CENPT ELMO3 LRRC29 CTCF FHOD1 LOC107984813 THAP11 TRADD TPPP3 KCTD19 FAM65A GFOD2 DUS2 B3GNT9 KIAA0895L AGRP NRN1L NOL3 PLEKHG4 E2F4 ATP6V0D1 EXOC3L1 SLC9A5 ENKD1

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding