Hs01107134_cn

• Gene Symbol: TRIB3
• Assay Reference Genome Location: Chr.20:397485 on build GRCh38
• Cytoband: 20p13

Target Gene Details

• Entrez Gene ID: 57761
• Gene Name: tribbles pseudokinase 3
• Gene Aliases: C20orf97, NIPK, SINK, SKIP3, TRB3
• Location: Chr.20:380629-397559 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRIB3	NM_001301188.1	4	1906	NP_001288117.1
	NM_001301190.1	4	1921	NP_001288119.1
	NM_001301193.1	4	2019	NP_001288122.1
	NM_001301196.1	4	2078	NP_001288125.1
	NM_001301201.1	5	2272	NP_001288130.1
	NM_021158.4	4	2413	NP_066981.2
	XM_017027989.1	4	2397	XP_016883478.1
	AJ697936.1	5	2256	CAG27047.1
	AK026945.1	5	2166	BAB15597.1
	AY247738.1	4	2412	AAP04407.1
	BC019363.1	4	1979	AAH19363.1
	BC027484.1	4	2166	AAH27484.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3644953	Chr.20:397290 - 502310 on Build GRCh38	Gain	TBC1D20 CSNK2A1 TRIB3 RBCK1
esv3644951	Chr.20:385214 - 399104 on Build GRCh38	Loss	TRIB3
esv3644952	Chr.20:386013 - 1119183 on Build GRCh38	Gain	FAM110A TBC1D20 SLC52A3 TCF15 LOC105372493 RBCK1 ANGPT4 PSMF1 SRXN1 RSPO4 CSNK2A1 SCRT2 TRIB3
nsv510777	Chr.20:366849 - 416704 on Build GRCh38	Deletion	TRIB3 RBCK1
nsv585170	Chr.20:380145 - 422066 on Build GRCh38	Loss	TRIB3 RBCK1
esv2657243	Chr.20:385360 - 399238 on Build GRCh38	Deletion	TRIB3
dgv4219n100	Chr.20:80652 - 461103 on Build GRCh38	Gain	DEFB129 TBC1D20 DEFB125 DEFB128 SOX12 DEFB127 ZCCHC3 RBCK1 DEFB132 LOC101929937 NRSN2-AS1 NRSN2 TRIB3 C20orf96 DEFB126
esv3893263	Chr.20:216521 - 434561 on Build GRCh38	Loss	LOC101929937 DEFB129 NRSN2-AS1 SOX12 NRSN2 TRIB3 C20orf96 ZCCHC3 RBCK1 DEFB132

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of protein kinase activity
regulation of glucose transport
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
response to endoplasmic reticulum stress
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Function(s)

transcription corepressor activity
protein kinase inhibitor activity
protein binding
ATP binding
kinase activity
protein kinase binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity