Hs01148950_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67198375 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Within Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3	10	1557	NP_001941.2
	BC033180.1	10	1510	AAH33180.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	C16orf86 ENKD1 ELMO3 NRN1L FAM65A ACD SLC9A5 LOC100505942 PSKH1 EXOC3L1 LOC100131303 NUTF2 SLC12A4 FHOD1 KCTD19 LRRC36 DUS2 CARMIL2 DDX28 HSF4 EDC4 TRADD E2F4 LOC105369155 MIR328 LRRC29 CENPT HSD11B2 LOC107984813 TMEM208 TPPP3 DPEP2 GFOD2 CTCF KIAA0895L DPEP3 ZDHHC1 PSMB10 RANBP10 ATP6V0D1 AGRP LCAT CTRL FBXL8 THAP11 NOL3 TSNAXIP1 PARD6A PLEKHG4
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	FBXL8 HSF4 ELMO3 TRADD E2F4 LOC105369155 KIAA0895L NOL3 SLC9A5 B3GNT9 C16orf70 MIR328 EXOC3L1 LRRC29 PLEKHG4 TMEM208 FHOD1
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	FBXL8 HSF4 ELMO3 TRADD E2F4 LOC105369155 KIAA0895L NOL3 B3GNT9 C16orf70 MIR328 EXOC3L1 LRRC29 TMEM208 FHOD1
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	FBXL8 LRRC29 HSF4 ELMO3 E2F4 LOC105369155 KIAA0895L NOL3 MIR328 EXOC3L1
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	LRRC29 ELMO3 E2F4 LOC105369155 KIAA0895L PLEKHG4 SLC9A5 TMEM208 FHOD1 MIR328 EXOC3L1
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	ELMO3 E2F4 LOC105369155 KIAA0895L NOL3 SLC9A5 MIR328 EXOC3L1 LRRC29 PLEKHG4 TMEM208 FHOD1 KCTD19
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	C16orf86 ENKD1 ELMO3 NRN1L FAM65A ACD SLC9A5 LOC100505942 PSKH1 EXOC3L1 LOC100131303 NUTF2 SLC12A4 FHOD1 KCTD19 LRRC36 DUS2 CARMIL2 DDX28 HSF4 EDC4 TRADD E2F4 LOC105369155 B3GNT9 C16orf70 MIR328 LRRC29 CENPT HSD11B2 LOC107984813 TMEM208 TPPP3 DPEP2 GFOD2 CTCF KIAA0895L DPEP3 ZDHHC1 PSMB10 RANBP10 ATP6V0D1 AGRP LCAT CTRL FBXL8 THAP11 NOL3 TSNAXIP1 PARD6A PLEKHG4

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding