Hs01280891_cn

• Gene Symbol: DOCK1
• Assay Reference Genome Location: Chr.10:127177077 on build GRCh38
• Cytoband: 10q26.2

Target Gene Details

• Entrez Gene ID: 1793
• Gene Name: dedicator of cytokinesis 1
• Gene Aliases: DOCK180, ced5
• Location: Chr.10:126905409-127452517 on Build GRCh38
• Assay Gene Location: Within Intron 30

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DOCK1	NM_001290223.1			NP_001277152.1
	NM_001380.4			NP_001371.1
	XM_011539422.2			XP_011537724.1
	XM_011539424.1			XP_011537726.1
	XM_017015813.1			XP_016871302.1
	XM_017015814.1			XP_016871303.1
	XM_017015815.1			XP_016871304.1
	XM_017015816.1			XP_016871305.1
	BC146857.1
	D50857.1			BAA09454.1

Target Gene Details

• Entrez Gene ID: 642938
• Gene Name: family with sequence similarity 196 member A
• Gene Aliases: C10orf141
• Location: Chr.10:127135426-127196522 on Build GRCh38
• Assay Gene Location: Within Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FAM196A	NM_001039762.2	3	351	NP_001034851.1
	XM_005252694.3			XP_005252751.1
	XM_017016537.1	2	3446	XP_016872026.1
	XM_017016538.1	3	2862	XP_016872027.1
	XM_017016539.1	2	589	XP_016872028.1
	XM_017016540.1	3	715	XP_016872029.1
	XM_017016541.1	2	151	XP_016872030.1
	XM_017016542.1	2	3446	XP_016872031.1
	XM_017016543.1	2	151	XP_016872032.1
	AK127465.1	3	351	BAC86991.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv1418n54	Chr.10:127176992 - 127190882 on Build GRCh38	Loss	DOCK1 FAM196A
nsv1045509	Chr.10:126162634 - 127193365 on Build GRCh38	Gain	LOC728158 DOCK1 LINC00601 C10orf90 FAM196A ADAM12
esv2759789	Chr.10:127110261 - 127440758 on Build GRCh38	Gain	DOCK1 FAM196A

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

guanyl-nucleotide exchange factor

Gene Ontology Categories:

Process(es)

phagocytosis, engulfment
apoptotic process
cytoskeleton organization
signal transduction
integrin-mediated signaling pathway
small GTPase mediated signal transduction
blood coagulation
positive regulation of epithelial cell migration
cell migration
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of GTPase activity
vascular endothelial growth factor receptor signaling pathway
positive regulation of substrate adhesion-dependent cell spreading

Function(s)

guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
GTPase activator activity
protein binding
SH3 domain binding