Hs01338243_cn

• Gene Symbol: DTX3
• Assay Reference Genome Location: Chr.12:57606228 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 196403
• Gene Name: deltex E3 ubiquitin ligase 3
• Gene Aliases: RNF154, deltex3
• Location: Chr.12:57604327-57609804 on Build GRCh38
• Assay Gene Location: Overlaps Exon 4 - Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DTX3	NM_001286245.1			NP_001273174.1
	NM_001286246.1			NP_001273175.1
	NM_178502.3			NP_848597.1
	XM_005268697.1			XP_005268754.1
	XM_005268698.1			XP_005268755.1
	XM_005268700.1			XP_005268757.1
	XM_005268703.1			XP_005268760.1
	XM_011538022.2			XP_011536324.1
	AK092085.1			BAC03801.1
	AK094385.1			BAC04344.1
	AK128752.1
	AL831941.1			CAD38593.2
	BC114441.1
	BC114498.1
	DA684401.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv428283	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	MIR6758 DCTN2 ARHGAP9 INHBC DDIT3 MBD6 MARS KIF5A GLI1 PIP4K2C DTX3 INHBE MIR616
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	MIR6758 DCTN2 ARHGAP9 DDIT3 LOC101927583 ARHGEF25 MBD6 MARS KIF5A GLI1 PIP4K2C DTX3 MIR616
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	OS9 GLS2 NABP2 LRP1-AS ARHGAP9 STAT6 SDR9C7 MBD6 CS MARS SNORD59B MIR616 SHMT2 PRIM1 SLC26A10 SNORA105C NDUFA4L2 B4GALNT1 SPRYD4 RBMS2 HBCBP KIF5A DTX3 SLC39A5 APOF R3HDM2 TAC3 MIR6758 MIR1228 NACA IL23A NXPH4 CNPY2 DDIT3 STAT2 GPR182 COQ10A BAZ2A MIP GLI1 PAN2 ATP5B PIP4K2C STAC3 RDH16 ANKRD52 SNORD59A DCTN2 HSD17B6 LRP1 PTGES3 INHBC LOC101927583 ZBTB39 ARHGEF25 RNF41 MYO1A NEMP1 INHBE TIMELESS NAB2

More Information

Additional Information:

For this assay, SNP(s) [rs75051978] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

Notch signaling pathway
protein ubiquitination

Function(s)

protein binding
zinc ion binding
ligase activity