Hs01351067_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143983595 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Within Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1	7	2230	NP_001304824.1
	NM_032789.4	8	2106	NP_116178.2
	NR_134234.1	8	2106
	XM_011517336.2	8	2046	XP_011515638.1
	AK027370.1	8	2063	BAB55067.1
	AK075250.1	4	793	BAC11498.1
	AK124017.1	1	764
	AK128537.1	9	1921
	AK129821.1	4	584
	AK222914.1	8	2089	BAD96634.1
	AK303317.1	7	2155
	BC014229.2	1	90	AAH14229.2
	BC019030.2	4	926	AAH19030.2
	BC132961.1	8	2057
	BC136542.1	8	2057

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	GRINA PARP10 PLEC
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	OPLAH MFSD3 MIR7112 CPSF1 LOC101928953 TONSL-AS1 TONSL EXOSC4 WDR97 HSF1 TMEM249 LOC101928902 PLEC DGAT1 MIR6848 MROH1 MIR6847 MIR939 SLC39A4 FOXH1 RECQL4 SPATC1 KIFC2 GPT MIR1234 SLC52A2 SCX VPS28 MAF1 CYC1 PARP10 SHARPIN SCRT1 FBXL6 CYHR1 BOP1 HGH1 GRINA MIR6893 GPAA1 SMPD5 ADCK5 MIR6849 PPP1R16A LRRC14 MIR6846 MIR661
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	OPLAH MFSD3 MIR7112 CPSF1 LOC101928953 TONSL-AS1 TONSL EXOSC4 WDR97 HSF1 TMEM249 LOC101928902 PLEC DGAT1 MIR6848 MROH1 MIR6847 MIR939 SLC39A4 FOXH1 RECQL4 SPATC1 KIFC2 GPT MIR1234 SLC52A2 SCX VPS28 MAF1 CYC1 PARP10 SHARPIN SCRT1 FBXL6 CYHR1 BOP1 HGH1 GRINA MIR6893 GPAA1 SMPD5 ADCK5 MIR6849 PPP1R16A LRRC14 MIR6846 MIR661
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	OPLAH MAF1 EXOSC4 WDR97 CYC1 PARP10 SHARPIN PLEC GRINA MIR6847 GPAA1 SMPD5 SPATC1 MIR6846
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	OPLAH MAF1 EXOSC4 WDR97 CYC1 PARP10 SHARPIN EPPK1 PLEC MROH1 HGH1 GRINA MIR6847 GPAA1 SMPD5 SPATC1 MIR6846 MIR661
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	OPLAH MAF1 EXOSC4 WDR97 CYC1 PARP10 SHARPIN EPPK1 PLEC GRINA MIR6847 GPAA1 SMPD5 SPATC1 MIR6846 MIR661
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	OPLAH LOC642574 MIR937 EXOSC4 SCRIB PARP10 EPPK1 PLEC GRINA MIR6847 MIR6845 NRBP2 SMPD5 SPATC1 MIR6846 MIR661 PUF60
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	OPLAH GRINA MIR6847 GPAA1 SMPD5 EXOSC4 CYC1 PARP10 SPATC1 MIR6846 MIR661 PLEC
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	OPLAH MAF1 EXOSC4 WDR97 CYC1 PARP10 SHARPIN PLEC GRINA MIR6847 GPAA1 SMPD5 SPATC1 MIR6846 MIR661
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	OPLAH GRINA MIR6847 GPAA1 SMPD5 EXOSC4 PARP10 SPATC1 MIR6846 MIR661 PLEC

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding