Hs01381567_cn

• Gene Symbol: TRIM28
• Assay Reference Genome Location: Chr.19:58547396 on build GRCh38
• Cytoband: 19q13.43

Target Gene Details

• Entrez Gene ID: 10155
• Gene Name: tripartite motif containing 28
• Gene Aliases: KAP1, PPP1R157, RNF96, TF1B, TIF1B
• Location: Chr.19:58544469-58550715 on Build GRCh38
• Assay Gene Location: Overlaps Intron 3 - Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRIM28	NM_005762.2			NP_005753.1
	AK225760.1
	AK313478.1
	BC004978.1			AAH04978.1
	BC052986.2			AAH52986.1
	U78773.1			AAB37341.1
	U95040.1			AAB51517.1
	X97548.1			CAA66150.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1057206	Chr.19:58546716 - 58586475 on Build GRCh38	Gain	MZF1-AS1 MIR6807 UBE2M MZF1 CENPBD1P1 CHMP2A TRIM28
dgv3687n100	Chr.19:58473466 - 58586475 on Build GRCh38	Gain	MZF1-AS1 MIR6807 UBE2M ZBTB45 MZF1 ZNF324 CENPBD1P1 ZNF446 CHMP2A SLC27A5 TRIM28
nsv515731	Chr.19:58320453 - 58576112 on Build GRCh38	Gain+Loss	A1BG CHMP2A MIR4754 MZF1-AS1 UBE2M ZNF497 LOC105372483 ZBTB45 ZNF324 TRIM28 MIR6807 ZNF584 ZNF837 MIR6806 ZNF132 MZF1 CENPBD1P1 SLC27A5 RNF225 ZSCAN22 A1BG-AS1 RPS5 ZNF324B LOC100506634 LOC100419840 ZNF446
nsv952156	Chr.19:58466134 - 58600733 on Build GRCh38	Deletion	MZF1-AS1 MIR6807 UBE2M ZBTB45 MZF1 ZNF324 CENPBD1P1 ZNF446 CHMP2A SLC27A5 TRIM28
nsv1160670	Chr.19:58433008 - 58586487 on Build GRCh38	Deletion	MIR6807 ZNF132 MZF1 CENPBD1P1 CHMP2A SLC27A5 MZF1-AS1 ZNF324B UBE2M ZBTB45 ZNF324 ZNF446 TRIM28
nsv828657	Chr.19:58483484 - 58585740 on Build GRCh38	Gain	MZF1-AS1 MIR6807 UBE2M ZBTB45 MZF1 CENPBD1P1 ZNF446 CHMP2A SLC27A5 TRIM28
dgv3688n100	Chr.19:58506055 - 58586475 on Build GRCh38	Gain	MZF1-AS1 MIR6807 UBE2M ZBTB45 MZF1 CENPBD1P1 CHMP2A SLC27A5 TRIM28
nsv1057077	Chr.19:58411953 - 58586475 on Build GRCh38	Gain	MIR6807 ZNF584 ZNF132 MZF1 CENPBD1P1 CHMP2A SLC27A5 MZF1-AS1 ZNF324B UBE2M ZBTB45 ZNF324 ZNF446 TRIM28

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
epithelial to mesenchymal transition
DNA repair
transcription initiation from RNA polymerase II promoter
Ras protein signal transduction
embryo implantation
protein ubiquitination
covalent chromatin modification
protein sumoylation
positive regulation of transcription factor import into nucleus
DNA methylation involved in embryo development
innate immune response
positive regulation of DNA repair
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
protein oligomerization
convergent extension involved in axis elongation
embryonic placenta morphogenesis
positive regulation of methylation-dependent chromatin silencing
negative regulation of DNA demethylation
negative regulation of viral release from host cell
regulation of genetic imprinting

Function(s)

RNA polymerase II transcription coactivator activity
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein kinase activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
ubiquitin protein ligase binding
Krueppel-associated box domain binding
sequence-specific DNA binding
poly(A) RNA binding
chromo shadow domain binding
promoter-specific chromatin binding